Journal ArticleDOI
Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis.
Reinaldo González-Ramos,Anne Van Langendonckt,Sylvie Defrère,Jean-Christophe Lousse,Sébastien Colette,Luigi Devoto,Jacques Donnez +6 more
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TLDR
In this article, the role of NF-κB in the pathogenesis of endometriosis has been evaluated using a literature search conducted in PubMed to identify all relevant citations, highlighting the important role of NGF in the pathwayophysiology of Endometria.About:
This article is published in Fertility and Sterility.The article was published on 2010-11-01. It has received 135 citations till now. The article focuses on the topics: Endometriosis & Proinflammatory cytokine.read more
Citations
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Endometriosis and possible inflammation markers
TL;DR: An overview of local microenvironmental inflammation and systemic inflammation biomarkers in endometriosis is provided and the identification of a noninvasive marker for endometRIosis will facilitate early diagnosis and treatment of this disease.
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P-selectin as a potential therapeutic target for endometriosis
TL;DR: Targeting P-selectin-mediated platelet adhesion onto endometriotic lesions holds promise as a novel therapeutics for treatingendometriosis.
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Curcumin and Endometriosis.
TL;DR: The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.
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A comprehensive review of hormonal and biological therapies for endometriosis: latest developments.
TL;DR: This review aims to give the reader a complete and updated overview of hormonal and biological therapies for the treatment of endometriosis, underlining the latest developments in this field of research.
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Endometriosis-Derived Stromal Cells Secrete Thrombin and Thromboxane A2, Inducing Platelet Activation
Sun-Wei Guo,Yanbo Du,Xishi Liu +2 more
TL;DR: It is found that EESCs secrete thrombin and TXA2 and induce platelet activation and aggregation in a density-dependent fashion and establishes that endometriotic lesions and platelets engage active cross-talks in the development ofendometriosis, highlighting the importance of lesion microenvironment in endometRIosis.
References
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.
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NF-κB at the crossroads of life and death
Michael Karin,Anning Lin +1 more
TL;DR: The choice between life and death is one of the major events in regulation of the immune system and a major regulator of such life or death decisions is the transcription factor NF-κB as mentioned in this paper.
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The two NF-κB activation pathways and their role in innate and adaptive immunity
Giuseppina Bonizzi,Michael Karin +1 more
TL;DR: Results strongly suggest that the classical and alternative pathways to NF-κB activation have distinct regulatory functions, one that is mostly involved in innate immunity and the other in adaptive immunity.
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Integrating cell-signalling pathways with NF-kappaB and IKK function.
TL;DR: This work has shown that crosstalk constitutes a decision-making process that determines the consequences of NF-κB and IKK activation and, ultimately, cell fate.