Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research
Paul A. Brogan,Amitabha Bose,David Burgner,D. Shingadia,Robert Tulloh,Colin Michie,Nigel Klein,Robert Booy,Michael Levin,M J Dillon +9 more
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TLDR
A clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date is proposed, and areas of practice where evidence is anecdotal or based on retrospective data are highlighted.Abstract:
This article proposes a clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date, and highlights areas of practice where evidence is anecdotal or based on retrospective data. Future research as proposed by the London Kawasaki Disease Research Group is outlined, and clinicians are invited to prospectively enrol their suspected cases into this collaborative research project.read more
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Management of Kawasaki disease
TL;DR: Recent advances in the understanding of KD pathogenesis and therapeutics are summarized, and an approach for managing KD patients in the UK in the light of these advances is provided.
Journal ArticleDOI
Intravenous immunoglobulin for the treatment of Kawasaki disease in children
Richmal Marie Oates‐Whitehead,J Harry Baumer,Linda Haines,Samantha Love,Ian Maconochie,Amit Gupta,Kevin S. Roman,Jaspal Dua,Ichiko Flynn +8 more
TL;DR: Evaluated randomised controlled trials of intravenous immunoglobulin to treat Kawasaki disease in children showed a significant decrease in new coronary artery abnormalities (CAAs) in favour of IVIG, and children fulfilling the diagnostic criteria for Kaw Osaka disease should be treated with IVIG within 10 days of onset of symptoms.
Journal ArticleDOI
Kawasaki disease: What is the epidemiology telling us about the etiology?
David Burgner,Anthony Harnden +1 more
TL;DR: The epidemiology of KD has been extensively investigated in many populations and provides much of the supporting evidence for the consensus regarding etiology, and these epidemiological data are reviewed here, in the context of the etiopathogenesis.
Journal Article
Mortality in systemic vasculitis: a systematic review.
R Phillip,Raashid Luqmani +1 more
TL;DR: The findings highlight the need to improve early diagnosis and initiation of targeted therapy, thereby reducing treatment-related toxicity and comorbidities in patients with systemic vasculitis.
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Commentary: diagnosis is based on clinical features
David Burgner,David Burgner +1 more
TL;DR: In this paper, the authors use molecular dynamics simulation results to discuss in a semi-quantitative manner different aspects of such segregation: how it varies within a homologous ionic liquid family, the influence of the nature of the ions in the morphology of the segregated domains; and the interactions of those domains with molecular solutes or solvents.
References
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Gastrointestinal hemorrhage complicating aspirin therapy in acute Kawasaki disease
Tomoyo Matsubara,Tomoyo Matsubara,Tomoyo Matsubara,Wilbert H. Mason,Wilbert H. Mason,Wilbert H. Mason,Iraj A. Kashani,Iraj A. Kashani,Iraj A. Kashani,Morton Kligerman,Morton Kligerman,Morton Kligerman,Jane C. Burns,Jane C. Burns,Jane C. Burns +14 more
TL;DR: Two children with typical KD who had massive gastrointestinal bleeding that required hospitalization and transfusion are described and appears to be a rare complication of salicylate therapy in patients with Kawasaki disease.
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Characterization of the T-cell receptor V-beta repertoire in Kawasaki disease.
Mancia L,Jan Wahlström,Schiller B,Chini L,Elinder G,P. D'Argenio,Dulceaydee Gigliotti,Hans Wigzell,Paolo Rossi,Paolo Rossi,Johan Grunewald +10 more
TL;DR: A significant increase in interleukin‐2 receptor (IL‐2R)‐expressing T lymphocytes restricted to the CD4+ subset was observed in KD patients, confirming a strong immune activation in KD that might be of importance in the pathogenesis of the disease.
Journal ArticleDOI
Erythropoiesis is distinct at each stage of ontogeny.
TL;DR: Fetal, newborn, and adult erythroid progenitor cultures are each unique with regard to erythropoietin sensitivity, growth time course, number of erystroid colonies, and the proportion of 7-globin synthesis.