Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research
Paul A. Brogan,Amitabha Bose,David Burgner,D. Shingadia,Robert Tulloh,Colin Michie,Nigel Klein,Robert Booy,Michael Levin,M J Dillon +9 more
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TLDR
A clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date is proposed, and areas of practice where evidence is anecdotal or based on retrospective data are highlighted.Abstract:
This article proposes a clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date, and highlights areas of practice where evidence is anecdotal or based on retrospective data. Future research as proposed by the London Kawasaki Disease Research Group is outlined, and clinicians are invited to prospectively enrol their suspected cases into this collaborative research project.read more
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Incomplete Kawaski disease: are we missing it?
TL;DR: A case report of a one and a half years old girl who came with features of incomplete Kawasaki disease, high grade fever, irritability, history of conjunctivitis and cracking of lips is presented.
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Vasculitis in children
TL;DR: This review describes the classification, diagnosis and management of the main primary systemic paediatric vasculitides, which include Henoch-Schonlein purpura, Kawasaki disease, Takayasu's arteritis, polyarteritis nodosa, and the ANCA associated vasculitic (AAV) conditions.
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Kawasaki disease in sulaymaniyah/ kurdistan/ iraq
TL;DR: Kawasaki disease is not uncommon in Sulaymaniyah, the clinical and epidemiological pattern is not different from other parts of the world, and the index of suspicion needs to be increased in order not to miss Kawasaki disease cases and avoid its serious cardiac complications.
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Clinical significance of follow-up laboratory tests, performed at 6 weeks after the onset of Kawasaki disease
TL;DR: ESR, CRP, and urinalysis performed at the 6 weeks after onset of KD is not significant for clinical information of progression, and platelet count should be estimated at 6th week for a judgement of continuous antiplatelet therapy.
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Reevaluation of the efficacy of intravenous gammaglobulin in the prevention and treatment of coronary artery lesion in Kawasaki disease.
TL;DR: IVIG treatment can remarkably shorten the course of patients with KD and decrease the incidence of CAL, but the efficacy of IVIG in the prevention and treatment of KD disease is not as expected by people, therefore, reevaluation of the practical efficacy ofIVIG is required.
References
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Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children
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In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
Valery Combes,Anne Christine Simon,Georges E. Grau,D. Arnoux,Laurence Camoin,Florence Sabatier,Murielle Mutin,Marielle Sanmarco,José Sampol,Françoise Dignat-George +9 more
TL;DR: Examination of morphological, immunological, and functional characteristics of MPs derived from human umbilical vein endothelial cells stimulated by TNF provides evidence that endothelial-derived MPs are detectable in normal human blood and are increased in patients with a coagulation abnormality characterized by the presence of lupus anticoagulant.
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The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment.
TL;DR: The incidence of CAA both at 30 and 60 days was significantly lower in low-IVig than in ASA and in high-IVIG than in low -IVIG groups, but this was noted at 30 days and not at 60 days.
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Kawasaki Disease: Effect of Treatment on Coronary Artery Involvement
TL;DR: The findings suggest that the steroid might act adversely to cause a progression of coronary lesions of the disease, and aspirin might act as the effective means for prevention of sudden death due to Kawasaki disease.