Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research
Paul A. Brogan,Amitabha Bose,David Burgner,D. Shingadia,Robert Tulloh,Colin Michie,Nigel Klein,Robert Booy,Michael Levin,M J Dillon +9 more
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TLDR
A clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date is proposed, and areas of practice where evidence is anecdotal or based on retrospective data are highlighted.Abstract:
This article proposes a clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date, and highlights areas of practice where evidence is anecdotal or based on retrospective data. Future research as proposed by the London Kawasaki Disease Research Group is outlined, and clinicians are invited to prospectively enrol their suspected cases into this collaborative research project.read more
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T cell Vbeta repertoires in childhood vasculitides.
TL;DR: Changes in the T cell Vβ repertoire in children with vasculitis over and above those observed in disease controls are observed, but this does not resolve unequivocally the question of the role of SAgs in childhood vasculitic syndromes.
Journal ArticleDOI
Kawasaki disease: a decade of experience from North India.
TL;DR: Kawasaki disease appears to occur at an older age in Indian children as compared to reports from Japan, and Irritability is a characteristic clinical finding, which needs to be considered in the differential diagnosis of all children with persistent unexplained fever.
Journal Article
Longterm outcomes in patients with giant aneurysms secondary to Kawasaki disease.
TL;DR: Regression of GA occurred in most of patients with KD, and minimal late ischemia was observed, and further studies are required to evaluate the use of oral anticoagulation in patients with GA secondary to KD.
Journal ArticleDOI
Endothelial microparticles and the diagnosis of the vasculitides.
Paul A. Brogan,Michael J. Dillon +1 more
TL;DR: The utility of EMP for the diagnosis and monitoring of active vasculitis is discussed and the potential for EMP to provide a window onto the activated endothelium in primary systemic vasculitides is examined.
Journal ArticleDOI
Immunoglobulin for rheumatic diseases in the twenty-first century: take it or leave it?
TL;DR: A thorough review of the current data on mechanisms of action, efficacy, and safety of intravenous immunoglobulins in rheumatic diseases demonstrates that the answer depends on the disease and the patients involved.
References
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Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children
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In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
Valery Combes,Anne Christine Simon,Georges E. Grau,D. Arnoux,Laurence Camoin,Florence Sabatier,Murielle Mutin,Marielle Sanmarco,José Sampol,Françoise Dignat-George +9 more
TL;DR: Examination of morphological, immunological, and functional characteristics of MPs derived from human umbilical vein endothelial cells stimulated by TNF provides evidence that endothelial-derived MPs are detectable in normal human blood and are increased in patients with a coagulation abnormality characterized by the presence of lupus anticoagulant.
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The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment.
TL;DR: The incidence of CAA both at 30 and 60 days was significantly lower in low-IVig than in ASA and in high-IVIG than in low -IVIG groups, but this was noted at 30 days and not at 60 days.
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Kawasaki Disease: Effect of Treatment on Coronary Artery Involvement
TL;DR: The findings suggest that the steroid might act adversely to cause a progression of coronary lesions of the disease, and aspirin might act as the effective means for prevention of sudden death due to Kawasaki disease.