Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research
Paul A. Brogan,Amitabha Bose,David Burgner,D. Shingadia,Robert Tulloh,Colin Michie,Nigel Klein,Robert Booy,Michael Levin,M J Dillon +9 more
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TLDR
A clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date is proposed, and areas of practice where evidence is anecdotal or based on retrospective data are highlighted.Abstract:
This article proposes a clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date, and highlights areas of practice where evidence is anecdotal or based on retrospective data. Future research as proposed by the London Kawasaki Disease Research Group is outlined, and clinicians are invited to prospectively enrol their suspected cases into this collaborative research project.read more
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Age no barrier to diagnosis
TL;DR: John was 14 years old when he was referred by his general practitioner (GP) with generalised stiffness in his legs and wrists for the past 4 days and complained of having had a frontal headache the previous day which had now resolved.
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A study of children with Kawasaki disease
TL;DR: All children clinically suspected to have KD, following admission to professorial unit at Lady Ridgeway Hospital for Children or when seen in the private sector from November 2001 to September 2002, were included in the study.
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New therapies for treating infections in infants and children
Saul N. Faust,S.B Welch,N Modi +2 more
TL;DR: Evidence for the use of novel or experimental treatments in serious bacterial infections and novel strategies to prevent infections in the community and in the hospital setting are examined.
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Kawasaki Disease Shock Syndrome Presented with Giant Coronary Artery Dilatation – Presentation of Two Cases and a Literature Review
TL;DR: Two adolescent boys who had KDSS are presented and their differentiating features from MIS-C are discussed and Pediatricians and paediatric cardiologists alike should be aware of this potentially severe form of manifestation of the Kawasaki disease.
References
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Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children
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In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
Valery Combes,Anne Christine Simon,Georges E. Grau,D. Arnoux,Laurence Camoin,Florence Sabatier,Murielle Mutin,Marielle Sanmarco,José Sampol,Françoise Dignat-George +9 more
TL;DR: Examination of morphological, immunological, and functional characteristics of MPs derived from human umbilical vein endothelial cells stimulated by TNF provides evidence that endothelial-derived MPs are detectable in normal human blood and are increased in patients with a coagulation abnormality characterized by the presence of lupus anticoagulant.
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The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment.
TL;DR: The incidence of CAA both at 30 and 60 days was significantly lower in low-IVig than in ASA and in high-IVIG than in low -IVIG groups, but this was noted at 30 days and not at 60 days.
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Kawasaki Disease: Effect of Treatment on Coronary Artery Involvement
TL;DR: The findings suggest that the steroid might act adversely to cause a progression of coronary lesions of the disease, and aspirin might act as the effective means for prevention of sudden death due to Kawasaki disease.