Journal ArticleDOI
Khayseneganins A-H, Limonoids from Khaya senegalensis
Chun-Mao Yuan,Yu Zhang,Gui-Hua Tang,Ying-Tong Di,Ming-Ming Cao,Xiao-Ying Wang,Guo-Ying Zuo,Shun-Lin Li,Hui-Ming Hua,Hongping He,Xiao-Jiang Hao +10 more
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TLDR
Eight new limonoid, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis and showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#).Abstract:
Eight new limonoids, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#), all with a MIC value of 12.5 mu g/mL.read more
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CMAUP: a database of collective molecular activities of useful plants.
Xian Zeng,Peng Zhang,Yali Wang,Chu Qin,Shangying Chen,Weidong He,Lin Tao,Lin Tao,Ying Tan,Dan Gao,Bohua Wang,Zhe Chen,Weiping Chen,Yuyang Jiang,Yu Zong Chen +14 more
TL;DR: A new database, Collective Molecular Activities of Useful Plants (CMAUP), is developed to provide the collective landscapes of multiple targets (ChEMBL target classes) and activity levels (in 2D target-ingredient heatmap), and regulated gene ontologies, biological pathways, processes and diseases for 5645 plants collected from or traditionally used in 153 countries and regions.
Journal ArticleDOI
Isolation and Asymmetric Total Synthesis of Perforanoid A.
Chao Lv,Xiao-Hui Yan,Qian Tu,Ying-Tong Di,Chun-Mao Yuan,Xin Fang,Yaacove Ben-David,Lei Xia,Jianxian Gong,Yuemao Shen,Zhen Yang,Xiao-Jiang Hao +11 more
TL;DR: Preliminary studies show that perforanoid A is cytotoxic towards HEL, K562, and CB3 tumor cell lines.
Journal ArticleDOI
Antiviral Limonoids Including Khayanolides from the Trang Mangrove Plant Xylocarpus moluccensis
Wanshan Li,Zhong-Ping Jiang,Li Shen,Patchara Pedpradab,Torsten Bruhn,Jun Wu,Gerhard Bringmann +6 more
TL;DR: Eight new khayanolides, named thaixylomolins G-N, two new phragmalins, and two new mexicanolides were obtained from the seeds of the Trang mangrove plant Xylocarpus moluccensis, and the antiviral activities of the isolates against pandemic influenza A virus (subtype H1N1) were tested by the assay of cytopathic effect inhibition.
Journal ArticleDOI
Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids from Trichilia connaroides.
Fa-Liang An,Jun Luo,Rui-Jun Li,Jian-Guang Luo,Xiao-Bing Wang,Ming-Hua Yang,Lei Yang,Hequan Yao,Hongbin Sun,Yi-Jun Chen,Ling-Yi Kong +10 more
TL;DR: Spirotrichilins A and B, two novel limonoids with an unprecedented spiro[cyclopenta[b]furan-2,1'-cyclopentan] ring system in A/B/C rings, were isolated from the fruits of trichilia connaroides and their planar structures and absolute configurations were established.
Journal ArticleDOI
Five-Membered Ring Systems: Furans and Benzofurans
TL;DR: In this paper, a review covers work published in the calendar year 2012 and references to new, naturally occurring furans, dihydrofurans, and tetrahydrofurants are given.
References
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Book
Circular Dichroism: Principles and Applications
TL;DR: Partial TABLE of CONTENTS: Circular Dichroism: An Introduction.
Journal ArticleDOI
In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae).
TL;DR: The crude extract from the bark and seeds of Khaya grandifoliola was active in vitro against Plasmodium falciparum and exhibited an additive effect when combined with chloroquine.
Journal ArticleDOI
The Advances in the Limonoid Chemistry of the Meliaceae Family
TL;DR: The Meliaceae family is rich sources of limonoid (meliacin), which are well known for their antifeedant activity and bitterness as mentioned in this paper, although their existence also could be found in Rutaceae, Cneoraceae, Ptaeroxylaceae, and Simaroubaceae family.
Journal ArticleDOI
Constituents of the seeds of Swietenia mahagoni Jacq. I. Isolation, structures, and 1H- and 13C-nuclear magnetic resonance signal assignments of new tetranortriterpenoids related to swietenine and swietenolide.
TL;DR: In this paper, the tetranortriterpenoids were isolated from the cotyledons of Swietenia mahagoni (Meliaceae) along with the known tetranORTriterpenoid.
Journal ArticleDOI
Aphanamixoid A, a Potent Defensive Limonoid, with a New Carbon Skeleton from Aphanamixis polystachya
Jie-Yun Cai,Yu Zhang,Shi-Hong Luo,Duo-Zhi Chen,Gui-Hua Tang,Chun-Mao Yuan,Ying-Tong Di,Sheng-Hong Li,Xiao-Jiang Hao,Hongping He +9 more
TL;DR: The significant antifeedant activity of 1 against the generalist plant-feeding insect Helicoverpa armigera suggested it may be a potent defensive component of A. polystachya.