Leisure Time Physical Activity and Mortality: A Detailed Pooled Analysis of the Dose-Response Relationship
Hannah Arem,Steven C. Moore,Alpa V. Patel,Patricia Hartge,Amy Berrington de Gonzalez,Kala Visvanathan,Peter T. Campbell,M. Freedman,Elisabete Weiderpass,Hans-Olov Adami,Hans-Olov Adami,Martha S. Linet,I. Min Lee,Charles E. Matthews +13 more
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In this article, the authors quantify the dose-response association between leisure time physical activity and mortality and define the upper limit of benefit or harm associated with increased levels of physical activity.Abstract:
Importance The 2008 Physical Activity Guidelines for Americans recommended a minimum of 75 vigorous-intensity or 150 moderate-intensity minutes per week (7.5 metabolic-equivalent hours per week) of aerobic activity for substantial health benefit and suggested additional benefits by doing more than double this amount. However, the upper limit of longevity benefit or possible harm with more physical activity is unclear. Objective To quantify the dose-response association between leisure time physical activity and mortality and define the upper limit of benefit or harm associated with increased levels of physical activity. Design, Setting, and Participants We pooled data from 6 studies in the National Cancer Institute Cohort Consortium (baseline 1992-2003). Population-based prospective cohorts in the United States and Europe with self-reported physical activity were analyzed in 2014. A total of 661 137 men and women (median age, 62 years; range, 21-98 years) and 116 686 deaths were included. We used Cox proportional hazards regression with cohort stratification to generate multivariable-adjusted hazard ratios (HRs) and 95% CIs. Median follow-up time was 14.2 years. Exposures Leisure time moderate- to vigorous-intensity physical activity. Main Outcomes and Measures The upper limit of mortality benefit from high levels of leisure time physical activity. Results Compared with individuals reporting no leisure time physical activity, we observed a 20% lower mortality risk among those performing less than the recommended minimum of 7.5 metabolic-equivalent hours per week (HR, 0.80 [95% CI, 0.78-0.82]), a 31% lower risk at 1 to 2 times the recommended minimum (HR, 0.69 [95% CI, 0.67-0.70]), and a 37% lower risk at 2 to 3 times the minimum (HR, 0.63 [95% CI, 0.62-0.65]). An upper threshold for mortality benefit occurred at 3 to 5 times the physical activity recommendation (HR, 0.61 [95% CI, 0.59-0.62]); however, compared with the recommended minimum, the additional benefit was modest (31% vs 39%). There was no evidence of harm at 10 or more times the recommended minimum (HR, 0.69 [95% CI, 0.59-0.78]). A similar dose-response relationship was observed for mortality due to cardiovascular disease and to cancer. Conclusions and Relevance Meeting the 2008 Physical Activity Guidelines for Americans minimum by either moderate- or vigorous-intensity activities was associated with nearly the maximum longevity benefit. We observed a benefit threshold at approximately 3 to 5 times the recommended leisure time physical activity minimum and no excess risk at 10 or more times the minimum. In regard to mortality, health care professionals should encourage inactive adults to perform leisure time physical activity and do not need to discourage adults who already participate in high-activity levels.read more
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References
More filters
Journal ArticleDOI
Compendium of physical activities: an update of activity codes and MET intensities.
Barbara E. Ainsworth,William L. Haskell,Melicia C. Whitt,Melinda L. Irwin,A. M. Swartz,Scott J. Strath,O'Brien Wl,David R. Bassett,Kathryn H. Schmitz,Patricia O. Emplaincourt,David R. Jacobs,Arthur S. Leon +11 more
TL;DR: An updated version of the Compendium of Physical Activities, a coding scheme that classifies specific physical activity (PA) by rate of energy expenditure, is provided to enhance the comparability of results across studies using self-reports of PA.
Journal ArticleDOI
Physical Activity, All-Cause Mortality, and Longevity of College Alumni
TL;DR: With or without consideration of hypertension, cigarette smoking, extremes or gains in body weight, or early parental death, alumni mortality rates were significantly lower among the physically active than among less active men.
Journal ArticleDOI
The association of changes in physical-activity level and other lifestyle characteristics with mortality among men.
Ralph S. Paffenbarger,Robert T. Hyde,Alvin L. Wing,I-Min Lee,Dexter L. Jung,James B. Kampert +5 more
TL;DR: Starting moderately vigorous sports activity, quitting cigarette smoking, maintaining normal blood pressure, and avoiding obesity were separately associated with lower rates of death from all causes and from coronary heart disease among middle-aged and older men.
Journal ArticleDOI
Body-Mass Index and Mortality among 1.46 Million White Adults
Amy Berrington de Gonzalez,Patricia Hartge,James R. Cerhan,Alan J. Flint,Lindsay M. Hannan,Robert J. MacInnis,Robert J. MacInnis,Steven C. Moore,Geoffrey S. Tobias,Hoda Anton-Culver,Laura E. Beane Freeman,W. Lawrence Beeson,Sandra Clipp,Dallas R. English,Aaron R. Folsom,D. Michal Freedman,Graham G. Giles,Niclas Håkansson,Katherine D. Henderson,Judith Hoffman-Bolton,Jane A. Hoppin,Karen L. Koenig,I. Min Lee,Martha S. Linet,Yikyung Park,Gaia Pocobelli,Arthur Schatzkin,Howard D. Sesso,Elisabete Weiderpass,Bradley J. Willcox,Alicja Wolk,Anne Zeleniuch-Jacquotte,Walter C. Willett,Michael J. Thun +33 more
TL;DR: In white adults, overweight and obesity (and possibly underweight) are associated with increased all-cause mortality and the hazard ratios for the men were similar.
Journal ArticleDOI
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
Paul M. Ridker,Nancy R. Cook,I-Min Lee,David Gordon,J. Michael Gaziano,JoAnn E. Manson,Charles H. Hennekens,Julie E. Buring +7 more
TL;DR: This large, primary-prevention trial among women showed that aspirin significantly reduced the risk of major cardiovascular events, ischemic stroke, and myocardial infarction among women 65 years of age or older.