Levetiracetam in pregnancy: Results from the UK and Ireland epilepsy and pregnancy registers
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TLDR
There is an error in the body of the abstract and in table 1 that the polytherapy major congenital malformations (MCM) rate should read 5.56% (3.54%–8.56%) rather than 6.47% (4.31%–9.60%).Abstract:
In the article “Levetiracetam in pregnancy: Results from the UK and Ireland epilepsy and pregnancy registers” by E. Mawhinney et al. ( Neurology® 2013;80:400–405), there is an error in the body of the abstract and in table 1. The polytherapy major congenital malformations (MCM) rate should read 5.56% (3.54%–8.56%) rather than 6.47% (4.31%–9.60%). The authors regret the errors.read more
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Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry
Torbjörn Tomson,Torbjörn Tomson,Dina Battino,Erminio Bonizzoni,John Craig,Dick Lindhout,Emilio Perucca,Anne Sabers,Sanjeev V Thomas,Frank J.E. Vajda,Francesca Faravelli,Chiara Pantaleoni,Elisabeth Robert-Gnansia,Leonor Cabral-Lim,Boštjan Čebular,Alejandro De Marinis,Reetta Kälviäinen,Ketevan Khomeriki,Gordana Kiteva-Trencevska,Silvia Kochen,Martin Kurthen,Gerhard Luef,Meritxell Martinez Ferri,Maja Milovanovic,Karl O. Nakken,Miri Neufeld,Hideyuki Ohtani,Aline Russell,Vladimír Safcák,Bettina Schmitz,Luigi Maria Specchio,Barbara Tettenborn,Eugène van Puijenbroek,Hsiang-Yu Yu,Jana Zárubová,Claus Albretsen,Silje Alvestad,Noémi Becser Andersen,Luisa Antonini,Jens Arentsen,Dag Aurlien,Ismael Barzinji,Juan Luis Becerra Cuñat,Natalia Bohorquez Morera,Martin J. Brodie,Eylert Brodtkorb,Laura Broglio,Elsebeth Bruun Christensen,Petr Bušek,Claudia Cagnetti,Maria Paola Canevini,Astrid Carius,Maria Dolores Castro Vilanova,Michela Cecconi,T.-Y. Chang,Jakob Christensen,Giovanni De Maria,Dieter Dennig,Brenda Diputado,Janne Marit Ertresvåg,Toni Escartin,Dominique Flügel,Birgitte Forsom Sondal,Nicoletta Foschi,Albertina Franza,Katsuyuki Fukushima,Antonio Gambardella,Iñigo Garamendi Ruiz,Helena Gauffin,Pia Gellert,Leif Gjerstad,Lisa Gordon,Katrine Haggag,Imad Halawa,Terttu Heikinheimo-Connell,Tim Hendgen,Zarouhi Hertz,Odo Hildenhagen,Stephanie Hödl,Ineke Hogenesch,Anette Huuse Farmen,Yushi Inoue,Stefan Juhl,Masaaki Kato,Germaine Kenou Van Rijckevorssel,E. Kluck,Hana Krijtová,Eva Kumlien,Angelo Labate,Theresa Lasch,Hans Lindsten,Renata Listonova,Rasmus Lossius,Anders Lundgren,Kristina Malmgren,Iva Marečková,Daniela Marino,Peter Mattsson,Aileen McGonigal,Katarzyna Miesczanleh,Masahiro Mizobuchi,Barbara Mostacci,Birgit Müffelmann,Uden Navn,Anders Nilsson,Bernhard Oehl,Andrea Ortenzi,Judith Osseforth,Aldo Paggi,Eliana Pastor,Birthe Pedersen,Vaiva Petrenaite,Pietro Pignatta,Isabel Pires,Alessandra Pistelli,Jesús Antonio Riuz Gimenez,Raffaele Rocchi,Lone Rodam,Reina Roivainen,Gisela Rytířová,Christian Samsonsen,Gemma Sansa Fayos,Anna Maija Saukkonen,Alma Sikiric,David Sopelana Garay,Bernhard J. Steinhoff,Maria Strandberg,Torleiv Svendsen,Erik Tauboll,Kiyohito Terada,Marina Trivisano,Katherine Turner,Mogens Worm,Elias Zakharia,Elena Zambrelli,Morteza Zarifi-Oskoie +135 more
TL;DR: Risks of major congenital malformation associated with lamotrigine, levetiracetam, and oxcarbazepine were within the range reported in the literature for offspring unexposed to antiepileptic drugs, and rational selection of these drugs is facilitated.
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Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
William T. Hu,Holtzman David M,Anne M. Fagan,Leslie M. Shaw,Richard J. Perrin,Steven E. Arnold,Murray Grossman,Chengjie Xiong,Rebecca Craig-Schapiro,Christopher M. Clark,Eve H. Pickering,Max Kuhn,Yu Chen,Vivianna M. Van Deerlin,Leo McCluskey,Lauren Elman,Jason Karlawish,Alice Chen-Plotkin,Howard I. Hurtig,Andrew Siderowf,Frank Swenson,Virginia M.-Y. Lee,John C. Morris,John Q. Trojanowski,Holly Soares +24 more
TL;DR: Four plasma analytes were consistently associated with the diagnosis of very mild dementia/MCI/AD in 3 independent clinical cohorts, and these plasma biomarkers may predict underlying AD through their association with CSF AD biomarkers.
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Valproate in the treatment of epilepsy in girls and women of childbearing potential
Torbjörn Tomson,Anthony G Marson,Anthony G Marson,Paul Boon,Maria Paola Canevini,Athanasios Covanis,Eija Gaily,Reetta Kälviäinen,Eugen Trinka +8 more
TL;DR: This document provides guidance on the use of valproate in girls and women of childbearing age from a joint Task Force of the Commission on European Affairs and the International League Against Epilepsy, following strengthened warnings from the Coordination Group for Mutual Recognition and Decentralised Procedures‐Human.
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Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate
Rebecca Bromley,Rebecca Calderbank,Christopher P Cheyne,Claire Rooney,Penny Trayner,Jill Clayton-Smith,Marta García-Fiñana,B. Irwin,James I. Morrow,Rebekah Shallcross,Rebekah Shallcross,Gus A. Baker +11 more
TL;DR: Preconception counseling should include discussion of neurodevelopmental outcomes for specific treatments and their doses and women should be made aware of the limited nature of the evidence base for newer antiepileptic drugs.
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Teratogenicity of antiepileptic drugs.
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References
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Journal ArticleDOI
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry
Torbjörn Tomson,Torbjörn Tomson,Dina Battino,Erminio Bonizzoni,John Craig,Dick Lindhout,Emilio Perucca,Anne Sabers,Sanjeev V Thomas,Frank J.E. Vajda,Francesca Faravelli,Chiara Pantaleoni,Elisabeth Robert-Gnansia,Leonor Cabral-Lim,Boštjan Čebular,Alejandro De Marinis,Reetta Kälviäinen,Ketevan Khomeriki,Gordana Kiteva-Trencevska,Silvia Kochen,Martin Kurthen,Gerhard Luef,Meritxell Martinez Ferri,Maja Milovanovic,Karl O. Nakken,Miri Neufeld,Hideyuki Ohtani,Aline Russell,Vladimír Safcák,Bettina Schmitz,Luigi Maria Specchio,Barbara Tettenborn,Eugène van Puijenbroek,Hsiang-Yu Yu,Jana Zárubová,Claus Albretsen,Silje Alvestad,Noémi Becser Andersen,Luisa Antonini,Jens Arentsen,Dag Aurlien,Ismael Barzinji,Juan Luis Becerra Cuñat,Natalia Bohorquez Morera,Martin J. Brodie,Eylert Brodtkorb,Laura Broglio,Elsebeth Bruun Christensen,Petr Bušek,Claudia Cagnetti,Maria Paola Canevini,Astrid Carius,Maria Dolores Castro Vilanova,Michela Cecconi,T.-Y. Chang,Jakob Christensen,Giovanni De Maria,Dieter Dennig,Brenda Diputado,Janne Marit Ertresvåg,Toni Escartin,Dominique Flügel,Birgitte Forsom Sondal,Nicoletta Foschi,Albertina Franza,Katsuyuki Fukushima,Antonio Gambardella,Iñigo Garamendi Ruiz,Helena Gauffin,Pia Gellert,Leif Gjerstad,Lisa Gordon,Katrine Haggag,Imad Halawa,Terttu Heikinheimo-Connell,Tim Hendgen,Zarouhi Hertz,Odo Hildenhagen,Stephanie Hödl,Ineke Hogenesch,Anette Huuse Farmen,Yushi Inoue,Stefan Juhl,Masaaki Kato,Germaine Kenou Van Rijckevorssel,E. Kluck,Hana Krijtová,Eva Kumlien,Angelo Labate,Theresa Lasch,Hans Lindsten,Renata Listonova,Rasmus Lossius,Anders Lundgren,Kristina Malmgren,Iva Marečková,Daniela Marino,Peter Mattsson,Aileen McGonigal,Katarzyna Miesczanleh,Masahiro Mizobuchi,Barbara Mostacci,Birgit Müffelmann,Uden Navn,Anders Nilsson,Bernhard Oehl,Andrea Ortenzi,Judith Osseforth,Aldo Paggi,Eliana Pastor,Birthe Pedersen,Vaiva Petrenaite,Pietro Pignatta,Isabel Pires,Alessandra Pistelli,Jesús Antonio Riuz Gimenez,Raffaele Rocchi,Lone Rodam,Reina Roivainen,Gisela Rytířová,Christian Samsonsen,Gemma Sansa Fayos,Anna Maija Saukkonen,Alma Sikiric,David Sopelana Garay,Bernhard J. Steinhoff,Maria Strandberg,Torleiv Svendsen,Erik Tauboll,Kiyohito Terada,Marina Trivisano,Katherine Turner,Mogens Worm,Elias Zakharia,Elena Zambrelli,Morteza Zarifi-Oskoie +135 more
TL;DR: Risks of major congenital malformation associated with lamotrigine, levetiracetam, and oxcarbazepine were within the range reported in the literature for offspring unexposed to antiepileptic drugs, and rational selection of these drugs is facilitated.
Journal ArticleDOI
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
William T. Hu,Holtzman David M,Anne M. Fagan,Leslie M. Shaw,Richard J. Perrin,Steven E. Arnold,Murray Grossman,Chengjie Xiong,Rebecca Craig-Schapiro,Christopher M. Clark,Eve H. Pickering,Max Kuhn,Yu Chen,Vivianna M. Van Deerlin,Leo McCluskey,Lauren Elman,Jason Karlawish,Alice Chen-Plotkin,Howard I. Hurtig,Andrew Siderowf,Frank Swenson,Virginia M.-Y. Lee,John C. Morris,John Q. Trojanowski,Holly Soares +24 more
TL;DR: Four plasma analytes were consistently associated with the diagnosis of very mild dementia/MCI/AD in 3 independent clinical cohorts, and these plasma biomarkers may predict underlying AD through their association with CSF AD biomarkers.
Journal ArticleDOI
Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis
Rebecca Craig-Schapiro,Max Kuhn,Chengjie Xiong,Eve H. Pickering,Jingxia Liu,Thomas P. Misko,Richard J. Perrin,Kelly R. Bales,Holly Soares,Anne M. Fagan,David M. Holtzman +10 more
TL;DR: A targeted proteomics approach to discover novel cerebrospinal fluid (CSF) biomarkers that can augment the diagnostic and prognostic accuracy of current leading CSF biomarkers (Aβ42, tau, p-tau181) and identify a novel biomarker (calbindin) with significant prognostic potential.
Journal ArticleDOI
Valproate in the treatment of epilepsy in girls and women of childbearing potential
Torbjörn Tomson,Anthony G Marson,Anthony G Marson,Paul Boon,Maria Paola Canevini,Athanasios Covanis,Eija Gaily,Reetta Kälviäinen,Eugen Trinka +8 more
TL;DR: This document provides guidance on the use of valproate in girls and women of childbearing age from a joint Task Force of the Commission on European Affairs and the International League Against Epilepsy, following strengthened warnings from the Coordination Group for Mutual Recognition and Decentralised Procedures‐Human.
Journal ArticleDOI
Proteomic analysis of the brain in Alzheimer's disease: molecular phenotype of a complex disease process.
TL;DR: Comparative proteome analysis is a method with the power to develop important new insights into pathogenic mechanisms in the dementias and provide a unique snapshot illustrating the complexity of interrelated disease mechanisms at work in a complex, multifactorial disease.