Linear and Nonlinear Mendelian Randomization Analyses of the Association Between Diastolic Blood Pressure and Cardiovascular Events: The J-Curve Revisited.
Marios Arvanitis,Guanghao Qi,Deepak L. Bhatt,Wendy S. Post,Nilanjan Chatterjee,Alexis Battle,John W. McEvoy,John W. McEvoy +7 more
TLDR
In this analysis of the genetic effect of DBP, there is no evidence for a non-linear J- or U-shaped relationship between DBP and adverse CVD outcomes; including MI.Abstract:
Background: Recent clinical guidelines support intensive blood pressure treatment targets. However, observational data suggest that excessive diastolic blood pressure (DBP) lowering might increase ...read more
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Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease
Kiran J Biddinger,Connor A. Emdin,Mary E. Haas,Minxian Wang,George Hindy,Patrick T. Ellinor,Sekar Kathiresan,Amit Khera,Krishna G. Aragam +8 more
TL;DR: Alcohol consumption at all levels was associated with increased risk of cardiovascular disease, but clinical and public health guidance should account for the considerable differences in cardiovascular risk across different levels of alcohol consumption, even those within current guideline-recommended limits.
Journal ArticleDOI
Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics
TL;DR: A unified MR approach, MR-APSS, is proposed, which accounts for pleiotropy and sample structure simultaneously by leveraging genome-wide information and allows to include more genetic variants with moderate effects as instrument variables (IVs) to improve statistical power without inflating type I errors.
Journal ArticleDOI
Obesity As A Causal Risk Factor For Aortic Valve Stenosis
TL;DR: In this article, a Mendelian randomization design was used to investigate genetic and observational associations of obesity measured by body mass index is causally associated with risk of aortic valve stenosis and replacement.
Journal ArticleDOI
Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length
Paddy C. Dempsey,Crispin Musicha,Alex V. Rowlands,Melanie J. Davies,Kamlesh Khunti,Cameron Razieh,Iain R Timmins,Francesco Zaccardi,Veryan Codd,Christopher P. Nelson,Tom Yates,Nilesh J. Samani +11 more
TL;DR: In this paper , the authors investigated whether walking pace is associated with leucocyte telomere length (LTL), which is causally associated with several chronic diseases and has been proposed as a marker of biological age.
Journal ArticleDOI
Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study.
TL;DR: In this article, a Mendelian randomization (MR) analysis was performed using a large-scale RA genome-wide association study (GWAS) dataset (462,933 cases and 457,732 controls).
References
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A Randomized Trial of Intensive versus Standard Blood-Pressure Control
Jackson T. Wright,Jeff D. Williamson,Paul K. Whelton,Joni K. Snyder,Kaycee M. Sink,Michael V. Rocco,David M. Reboussin,Mahboob Rahman,Mahboob Rahman,Suzanne Oparil,Cora E. Lewis,Paul L. Kimmel,Karen C. Johnson,David C. Goff,Lawrence J. Fine,Jeffrey A. Cutler,William C. Cushman,Alfred K. Cheung,Walter T. Ambrosius +18 more
TL;DR: In this article, the most appropriate targets for systolic blood pressure to reduce cardiovascular morbidity and mortality among persons without diabetes remain uncertain, and the authors propose a target of less than 120 mm Hg.
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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
TL;DR: An adaption of Egger regression can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is not subject to these violations, and provides a sensitivity analysis for the robustness of the findings from a Mendelian randomization investigation.
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Ezetimibe added to statin therapy after acute coronary syndromes
TL;DR: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes and lowering LDL cholesterol to levels below previous targets provided additional benefit.
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Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.
TL;DR: A novel weighted median estimator for combining data on multiple genetic variants into a single causal estimate is presented, which is consistent even when up to 50% of the information comes from invalid instrumental variables.
Journal ArticleDOI
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
TL;DR: Among patients at high risk for cardiovascular events but without diabetes, targeting a systolic blood pressure target of less than 120 mm Hg, as compared with less than 140 mm HG, resulted in lower rates of fatal and nonfatal major cardiovascular events and death from any cause, although significantly higher rates of some adverse events were observed in the intensive-treatment group.
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