LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9.
Zhiqiang Fu,Changhao Chen,Quanbo Zhou,Yinxue Wang,Yue Zhao,Xiaohui Zhao,Wenzhu Li,Shangyou Zheng,Huilin Ye,Lin Wang,Zhanghai He,Qing Lin,Zhihua Li,Rufu Chen +13 more
TLDR
The results indicate that the HOTTIP/WDR5/HOXA9/Wnt axis contributes to PCSC stemness and is a potential therapeutic target for PDAC.About:
This article is published in Cancer Letters.The article was published on 2017-12-01 and is currently open access. It has received 158 citations till now. The article focuses on the topics: WDR5 & Cancer stem cell.read more
Citations
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The emerging role of lncRNAs in the regulation of cancer stem cells
TL;DR: lncRNAs are valuable tools in the search for new targets to selectively eliminate CSCs and improve clinical outcomes and may serve as excellent therapeutic targets because they are stable, easily detectable and expressed in tissue-specific contexts.
Journal ArticleDOI
lncRNA GAS5 Reverses EMT and Tumor Stem Cell-Mediated Gemcitabine Resistance and Metastasis by Targeting miR-221/SOCS3 in Pancreatic Cancer.
Bingyan Liu,Shaoqiu Wu,Jun Ma,Shuo Yan,Zhengguang Xiao,Linhuang Wan,Feng Zhang,Mingyi Shang,Aiwu Mao +8 more
TL;DR: In this article, the authors explored the potential functions and mechanisms of GAS5 in pancreatic cancer (PC) gemcitabine resistance and metastasis, and showed that overexpression of growth arrest-specific 5 suppressed the proliferation, migration and stem cell-like properties of PC cells by directly binding to and suppressing miR-221 expression.
Journal ArticleDOI
Long Noncoding RNA and Epithelial Mesenchymal Transition in Cancer.
Mila Gugnoni,Alessia Ciarrocchi +1 more
TL;DR: The findings on the role of lncRNAs on EMT regulation are summarized and their prospective potential value as biomarkers and therapeutic targets in cancer is discussed.
References
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Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
Journal ArticleDOI
Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Journal ArticleDOI
Identification of Pancreatic Cancer Stem Cells
Chenwei Li,David G. Heidt,Piero Dalerba,Charles F. Burant,Lanjing Zhang,Volkan Adsay,Max S. Wicha,Michael F. Clarke,Diane M. Simeone +8 more
TL;DR: This work identified a highly tumorigenic subpopulation of pancreatic cancer cells expressing the cell surface markers CD44, CD24, and epithelial-specific antigen (ESA) that showed the stem cell properties of self-renewal, the ability to produce differentiated progeny, and increased expression of the developmental signaling molecule sonic hedgehog.
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Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
Luca Quagliata,Matthias S. Matter,Salvatore Piscuoglio,Salvatore Piscuoglio,Leila Arabi,Christian Ruiz,Alfredo Procino,Michal Kovac,Francesca Moretti,Zuzanna Makowska,Tujana Boldanova,Jesper B. Andersen,Monika Hämmerle,Luigi Tornillo,Markus H. Heim,Sven Diederichs,Clemente Cillo,Luigi Terracciano +17 more