Journal ArticleDOI
Localization of neurotrophin-3-like immunoreactivity in the rat central nervous system
Xin-Fu Zhou,Robert A. Rush +1 more
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TLDR
The results suggest that some NT3 immunoreactive neurons in the central nervous system accumulate NT3 in accord with a neurotrophic role for their maintenance or survival, while others may synthesize and secrete the factor to provide support for innervating neurons.About:
This article is published in Brain Research.The article was published on 1994-04-18. It has received 113 citations till now. The article focuses on the topics: Motor neuron & Neurotrophin.read more
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Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.
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The induction of pain: an integrative review
TL;DR: A global account of mechanisms involved in the induction of pain is provided, including neuronal pathways for the transmission of nociceptive information from peripheral nerve terminals to the dorsal horn, and therefrom to higher centres.
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Neurotrophin secretion: current facts and future prospects
TL;DR: Since BDNF has been proposed to play a critical role as an intercellular synaptic messenger in long-term potentiation (LTP) in the hippocampus, this article tries to reconcile this possible role of BDNF in LTP with the recently described features of synaptic BDNF secretion.
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The role of neuronal growth factors in neurodegenerative disorders of the human brain
Bronwen Connor,Mike Dragunow +1 more
TL;DR: The role members of the nerve growth factor family (NGF, BDNF and NT-3) and trk receptors as well as additional growth factors (GDNF, TGF-alpha and IGF-I) may play in neurodegenerative disorders of the human brain are examined.
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Brain-Derived Neurotrophic Factor in Astrocytes, Oligodendrocytes, and Microglia/Macrophages after Spinal Cord Injury
TL;DR: In normal adult cord, astrocytes, oligodendrocycles, and microglia/macrophages play roles in local trophin availability and in trophIn-mediated injury and healing responses directly within and surrounding the wound site.
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Journal ArticleDOI
Purification of a new neurotrophic factor from mammalian brain.
TL;DR: This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties.
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Molecular cloning and expression of brain-derived neurotrophic factor.
Joachim Leibrock,Friedrich Lottspeich,Hohn Andreas,Magdalena Hofer,Bastian Hengerer,Piotr Masiakowski,Hans Thoenen,Yves-Alain Barde +7 more
TL;DR: The full primary structure of brain-derived neurotrophic factor is reported and it is established that these two neurotrophic factors are related both functionally and structurally.
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BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.
Carolyn Hyman,Magdalena Hofer,Yves-Alain Barde,M Juhasz,George D. Yancopoulos,Stephen P. Squinto,Ronald M. Lindsay +6 more
TL;DR: BRAIN-derived neurotrophic factor seems to be a trophic factor for mesencephalic dopaminergic neurons, increasing their survival, including that of neuronal cells which degenerate in Parkinson's disease.
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The trk proto-oncogene encodes a receptor for nerve growth factor.
TL;DR: The results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor.