Journal ArticleDOI
Localization of somatostatin-, substance P- and calcitonin-like immunoreactivity in the neural ganglion of Ciona intestinalis L. (Ascidiaceae).
TLDR
Indirect immunofluorescence studies using antisera to synthetic somatostatin, human calcitonin and substance P indicate, in the neural complex of the sea-squirt, Ciona intestinalis L., that these polypeptides are present in large perikarya situated at the periphery of the cerebral ganglion as well as in some smallerPerikarya in the medulla.Abstract:
Indirect immunofluorescence studies using antisera to synthetic somatostatin, human calcitonin and substance P indicate, in the neural complex of the sea-squirt, Ciona intestinalis L, that these polypeptides are present in large perikarya situated at the periphery of the cerebral ganglion as well as in some smaller perikarya in the medulla In the medullary and transitional zone, there are nerve fibres that cross-react positively with anti-calcitonin and antisubstance Pread more
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Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Michael G. Rosenfeld,Jean-Jacques Mermod,Susan G. Amara,Larry W. Swanson,Paul E. Sawchenko,Jean Rivier,Wylie Vale,Ronald M. Evans +7 more
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
Journal ArticleDOI
The tachykinin peptide family
TL;DR: An update on the current body of knowledge regarding tachykinin occurrence and distribution in the animal kingdom, from the lowest invertebrates to man, and the physiological and pharmacological actions of tachyKinins outlining the pregnant importance of this large peptide family is provided.
Journal ArticleDOI
Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat
TL;DR: It should be noted that somatostatin-positive cell bodies and fibers did not always conform to the boundaries of the classical neuroanatomical nuclei, but could often be found in areas between these well-established nuclei or occupying, in varying concentrations, only parts of such nuclei.
Journal ArticleDOI
The Tachykinin Peptide Family
Cinzia Severini,Giovanna Improta,Giuliana Falconieri-Erspamer,Severo Salvadori,Vittorio Erspamer +4 more
TL;DR: An update on the current body of knowledge regarding tachykinin occurrence and distribution in the animal kingdom, from the lowest invertebrates to man, and the physiological and pharmacological actions of tachyKinins outlining the pregnant importance of this large peptide family is provided.
References
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TL;DR: Small amounts of antibody were occasionally visible in cells in the lymphoid follicles of the spleen and lymph nodes, so that a minor contribution by lymphocytes to antibody synthesis cannot be excluded.
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The Regional Distribution of Somatostatin in the Rat Brain
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Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic d cells
TL;DR: Combined immunocytochemical methods, and histological methods for endocrine granules, have demonstrated that the normal pancreatic D cell contains a product with G.I.H.H-like immunoreactivity, which suggests that it may play an important role in digestive physiology.