Open AccessJournal Article
Long noncoding RNA ATB promotes osteosarcoma cell proliferation, migration and invasion by suppressing miR-200s
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TLDR
LncRNA-ATB may be a potential diagnostic and prognostic biomarker and a therapeutic target for osteosarcoma and Mechanistically, it is found that lncRNAs inhibits miR-200s, and upregulates miR -200s target genes ZEB1 and ZEB2.Abstract:
Long noncoding RNA activated by transforming growth factor-β (lncRNA-ATB) is a novel lncRNA, which is recently reported to have critical roles in carcinogenesis and progression of several cancers. However, the expression, clinical values, biological roles, and underlying molecular mechanisms of lncRNA-ATB in osteosarcoma are still known. In this study, we measured lncRNA-ATB expression in serum and osteosarcoma tissues of osteosarcoma patients, analyzed its diagnostic and prognostic values. Serum lncRNA-ATB is increased in osteosarcoma patients and could accurately discriminate osteosarcoma patients from healthy controls. LncRNA-ATB is also upregulated in osteosarcoma tissues and cell lines, and positively associated with Enneking stage, metastasis and recurrence. Increased lncRNA-ATB level indicates poor recurrence-free survival and overall survival. Functional experiments demonstrated that overexpression of lncRNA-ATB enhances osteosarcoma cells proliferation, migration, and invasion, and while depletion of lncRNA-ATB inhibits osteosarcoma cells proliferation, migration, and invasion. Mechanistically, we found that lncRNA-ATB inhibits miR-200s, and upregulates miR-200s target genes ZEB1 and ZEB2. Additionally, the roles of lncRNA-ATB on osteosarcoma cells proliferation, migration, and invasion in vitro, and osteosarcoma tumor growth in vivo are dependent on the regulation of miR-200s. Taken together, this study suggests that lncRNA-ATB may be a potential diagnostic and prognostic biomarker and a therapeutic target for osteosarcoma.read more
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Journal ArticleDOI
Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma
Jinyan Wang,Yan Yang,Yajun Ma,Fen Wang,Aili Xue,Jing Zhu,Hui Yang,Qi Chen,Meili Chen,Lingling Ye,Hao Wu,Quan’an Zhang +11 more
TL;DR: The role of lncRNA-miRNA-mRNA axis in the development of OS is highlighted to provide novel approaches for cancer diagnosis and treatment.
Journal ArticleDOI
Long noncoding RNA ATB promotes the epithelial-mesenchymal transition by upregulating the miR-200c/Twist1 axe and predicts poor prognosis in breast cancer.
Rong-Hui Li,Min Chen,Min Chen,Jing Liu,Chang-Chun Shao,Cui-Ping Guo,Xiao-Long Wei,Yao-Chen Li,Wen-He Huang,Guo-Jun Zhang,Guo-Jun Zhang +10 more
TL;DR: The upregulation of lncATB in breast cancer cells was validated in a TGF-β-induced EMT model and Twist1 was defined as a major target of lNCATBs in the induction of the EMT and highlighted as a biomarker in Breast cancer patients.
Journal ArticleDOI
The Role of Long Non-Coding RNAs in Osteosarcoma
Maria Anna Smolle,Martin Pichler +1 more
TL;DR: The role of lncRNAs with prognostic, predictive, therapeutic, and diagnostic significance in osteosarcoma is discussed and their potential application in clinical practice is highlighted.
Journal ArticleDOI
Emerging roles of non-coding RNAs in the pathogenesis, diagnosis and prognosis of osteosarcoma
TL;DR: This summary of current knowledge on the involvement of ncRNAs in OS will not only aid comprehension of the complex processes of OS initiation and progression but also contribute to the exploration of ideal diagnostic biomarkers and therapeutic targets for OS patients.
Journal ArticleDOI
The Function and Mechanism of Long Non-coding RNA-ATB in Cancers.
Huizhong Xiao,Fuyou Zhang,Yifan Zou,Yifan Zou,Jianfa Li,Jianfa Li,Yuchen Liu,Weiren Huang,Weiren Huang,Weiren Huang +9 more
TL;DR: It is concluded that lncRNA-ATB may provide a new biomarker for use in diagnosis and prognosis of cancer and induces epithelial-mesenchymal transition (EMT) by competitively binding to miRNAs, thus promoting tumor progression.
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TL;DR: Findings suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies.