Kata Fejes-Toth

TL;DR: Evidence that three-quarters of the human genome is capable of being transcribed is reported, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs that prompt a redefinition of the concept of a gene.

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: RNA-seq and functional experiments identify the transposon-derived gene ERNI as Piwil1’s target in the neural crest, and suppresses Sox2 to precisely control the timing of neural crest specification and EMT.

TL;DR: A proteomics-based strategy to characterize the SUMOylated proteome in Drosophila allowed us to identify ~1500 SUMO sites in 843 proteins in the fly ovary and it is shown thatsumOylation of several piRNA pathway proteins occurs in a Piwi-dependent manner, indicating a functional implication of this modification in the cellular response to transposon activity.