Journal ArticleDOI
Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis.
Krishan Kumar Thakur,Aviral Kumar,Kishore Banik,Elika Verma,Elina Khatoon,Choudhary Harsha,Gautam Sethi,Subash C. Gupta,Ajaikumar B. Kunnumakkara +8 more
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TLDR
In this paper, a review highlights the association of several lncRNAs in TNBC progression and treatment, along with their possible functions and mechanisms, and extensive research is being carried out to reveal it.Abstract:
In recent years, triple-negative breast cancer (TNBC) has emerged as the most aggressive subtype of breast cancer and is usually associated with increased mortality worldwide. The severity of TNBC is primarily observed in younger women, with cases ranging from approximately 12%-24% of all breast cancer cases. The existing hormonal therapies offer limited clinical solutions in completely circumventing the TNBC, with chemoresistance and tumor recurrences being the common hurdles in the path of TNBC treatment. Accumulating evidence has correlated the dysregulation of long noncoding RNAs (lncRNAs) with increased cell proliferation, invasion, migration, tumor growth, chemoresistance, and decreased apoptosis in TNBC. Various clinical studies have revealed that aberrant expression of lncRNAs in TNBC tissues is associated with poor prognosis, lower overall survival, and disease-free survival. Due to these specific characteristics, lncRNAs have emerged as novel diagnostic and prognostic biomarkers for TNBC treatment. However, the underlying mechanism through which lncRNAs perform their actions remains unclear, and extensive research is being carried out to reveal it. Therefore, understanding of mechanisms regulating the modulation of lncRNAs will be a substantial breakthrough in effective treatment therapies for TNBC. This review highlights the association of several lncRNAs in TNBC progression and treatment, along with their possible functions and mechanisms.read more
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Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Mahshid Deldar Abad Paskeh,Maliheh Entezari,Sepideh Mirzaei,Amirhossein Zabolian,Hossein Saleki,Mohamad Javad Naghdi,Sina J. Sabet,M. Khoshbakht,M. Hashemi,Kiavash Hushmandi,Gautam Sethi,Ali Zarrabi,Alan Prem Kumar,Shing Cheng Tan,N. Papadakis,Athanasios Alexiou,Md. Asiful Islam,Ebrahim Mostafavi,Milad Ashrafizadeh +18 more
TL;DR: The role of exosomes in cancer progression and therapy is discussed in this article , where the authors provide a comprehensive understanding of the role of the exosome in cancer therapy, focusing on their therapeutic value in cancer progress and remodeling of the tumor microenvironment.
Journal ArticleDOI
Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways.
TL;DR: In this article, the role of Wnt signaling in hepatocellular carcinoma (HCC) and its association with progression and therapy response based on pre-clinical and clinical evidence is discussed.
Journal ArticleDOI
Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?
Sepideh Mirzaei,Mahshid Deldar Abad Paskeh,Yalda Saghari,Ali Zarrabi,Michael R. Hamblin,Maliheh Entezari,M. Hashemi,Amir Reza Aref,Kiavash Hushmandi,Alan Prem Kumar,Navid Rabiee,Milad Ashrafizadeh,Saeed Samarghandian +12 more
TL;DR: In this article , the role of transforming growth factor-β (TGF-β) signaling in prostate cancer development and metastasis has been investigated, and the authors have shown that TGFβ up-regulation before prostatectomy is associated with recurrence of prostate cancer.
Journal ArticleDOI
Gene regulation by antisense transcription: A focus on neurological and cancer diseases.
Sajad Najafi,Shing Cheng Tan,Pourya Raee,Yazdan Rahmati,Yahya Asemani,E. Hui Clarissa Lee,Kiavash Hushmandi,Ali Zarrabi,Amir Reza Aref,Milad Ashrafizadeh,Alan Prem Kumar,Yavuz Nuri Ertas,Sepideh Ghani,Shahin Aghamiri +13 more
TL;DR: The NATs are known to concordantly and discordantly regulate gene expression in both cis and trans manners at the transcriptional, post-transcriptional, translational, and epigenetic levels.
Journal ArticleDOI
Gene regulation by antisense transcription: A focus on neurological and cancer diseases
TL;DR: The NATs are known to concordantly and discordantly regulate gene expression in both cis and trans manners at the transcriptional, post-transcriptional, translational, and epigenetic levels as mentioned in this paper .
References
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