Long-term Persistence of Zoster Vaccine Efficacy
Vicki A. Morrison,Gary R. Johnson,Kenneth E. Schmader,Myron J. Levin,Jane H. Zhang,David Looney,Robert F. Betts,Larry D. Gelb,John C. Guatelli,Ruth Harbecke,Connie Pachucki,Susan Keay,Barbara Menzies,Marie R. Griffin,Carol A. Kauffman,Adriana Marques,John F. Toney,Kathy D. Boardman,Shu-Chih Su,Xiaoming Li,Ivan S. F. Chan,Janie Parrino,Paula W. Annunziato,Michael N. Oxman +23 more
TLDR
Estimates of vaccine efficacy decreased over time in the LTPS population compared with modeled control estimates, and declined for all 3 outcome measures from 7 through 11 years postvaccination.Abstract:
Background. The Shingles Prevention Study (SPS) demonstrated zoster vaccine efficacy through 4 years postvaccination. A Short-Term Persistence Substudy (STPS) demonstrated persistence of vaccine efficacy for at least 5 years. A Long-Term Persistence Substudy (LTPS) was undertaken to further assess vaccine efficacy in SPS vaccine recipients followed for up to 11 years postvaccination. Study outcomes were assessed for the entire LTPS period and for each year from 7 to 11 years postvaccination.
Methods. Surveillance, case determination, and follow-up were comparable to those in SPS and STPS. Because SPS placebo recipients were offered zoster vaccine before the LTPS began, there were no unvaccinated controls. Instead, SPS and STPS placebo results were used to model reference placebo groups.
Results. The LTPS enrolled 6867 SPS vaccine recipients. Compared to SPS, estimated vaccine efficacy in LTPS decreased from 61.1% to 37.3% for the herpes zoster (HZ) burden of illness (BOI), from 66.5% to 35.4% for incidence of postherpetic neuralgia, and from 51.3% to 21.1% for incidence of HZ, and declined for all 3 outcome measures from 7 through 11 years postvaccination. Vaccine efficacy for the HZ BOI was significantly greater than zero through year 10 postvaccination, whereas vaccine efficacy for incidence of HZ was significantly greater than zero only through year 8.
Conclusions. Estimates of vaccine efficacy decreased over time in the LTPS population compared with modeled control estimates. Statistically significant vaccine efficacy for HZ BOI persisted into year 10 postvaccination, whereas statistically significant vaccine efficacy for incidence of HZ persisted only through year 8.read more
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References
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Journal ArticleDOI
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
Michael N. Oxman,Michael N. Oxman,Myron J. Levin,Gary R. Johnson,Kenneth E. Schmader,Sharon E. Straus,Lawrence D. Gelb,Robert D. Arbeit,Michael S. Simberkoff,Anne A. Gershon,Larry E. Davis,Adriana Weinberg,Kathy D. Boardman,Heather M. Williams,J. Hongyuan Zhang,Peter Peduzzi,C. E. Beisel,Vicki A. Morrison,John C. Guatelli,P. A. Brooks,C. A. Kauffman,Constance T. Pachucki,Kathleen M. Neuzil,Robert F. Betts,Peter F. Wright,Marie R. Griffin,P. Brunell,N. E. Soto,Adriana Marques,Susan Keay,R. P. Goodman,D. J. Cotton,John W. Gnann,J. Loutit,Mark Holodniy,Wendy A. Keitel,George E. Crawford,S. S. Yeh,Z. Lobo,John F. Toney,Richard N. Greenberg,Paul M. Keller,Ruth Harbecke,Anthony R. Hayward,Michael R. Irwin,Tassos C. Kyriakides,Christina Y. Chan,Ivan S. F. Chan,William Wang,Paula W. Annunziato,Jeffrey L. Silber +50 more
TL;DR: The zoster vaccine markedly reduced morbidity from herpes zoster and postherpetic neuralgia among older adults and significantly reduced the burden of illness due to herpesZoster.
Journal ArticleDOI
The nature of herpes zoster: a long-term study and a new hypothesis.
TL;DR: Herpes zoster represents an adaptation enabling varicella virus to survive for long periods, even without a continuous supply of persons susceptible to chickenpox.
Journal ArticleDOI
Population-based study of herpes zoster and its sequelae.
TL;DR: The dermatomal distribution of herpes zoster observed in Rochester was quite similar to previous studies, despite their inherent biases in case ascertainment, except for a lower proportion with cranial nerve zoster.
Journal ArticleDOI
Incidence of Herpes Zoster, Before and After Varicella-Vaccination-Associated Decreases in the Incidence of Varicella, 1992–2002
TL;DR: The findings revealed that the vaccination-associated decrease in varicella disease did not result in an increase in the incidence of HZ, and these early findings will have to be confirmed as the occurrence of varICElla disease continues to decrease.
Journal ArticleDOI
Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventory.
Paul Coplan,Paul Coplan,Kenneth E. Schmader,Alexander Nikas,Ivan S. F. Chan,Peter W. Choo,Myron J. Levin,Gary R. Johnson,Mark S. Bauer,Heather M. Williams,Karen M. Kaplan,Harry A. Guess,Michael N. Oxman +12 more
TL;DR: The Zoster Brief Pain Inventory (ZBPI) as mentioned in this paper is an HZ-specific questionnaire to quantify HZ pain and discomfort, an operational definition of postherpetic neuralgia (PHN), and a severity-duration measure of the burden of illness caused by HZ.
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