Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes.
Caitlin F Fowler,Caitlin F Fowler,Dana Goerzen,Dan Madularu,Dan Madularu,Dan Madularu,Gabriel A. Devenyi,Gabriel A. Devenyi,M. Mallar Chakravarty,M. Mallar Chakravarty,Jamie Near,Jamie Near +11 more
TLDR
In this paper, a comprehensive longitudinal examination of morphometric change in 73 brain regions and at a voxel-wise level during normative aging in vivo in a mixed-sex cohort of Fischer 344 rats was performed.About:
This article is published in Neurobiology of Aging.The article was published on 2022-01-01 and is currently open access. It has received 4 citations till now.read more
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Neurochemical and cognitive changes precede structural abnormalities in the TgF344-AD rat model
Caitlin F Fowler,Dana Goerzen,Gabriel A. Devenyi,Dan Madularu,M. Mallar Chakravarty,Jamie Near +5 more
TL;DR: Findings support the use of MRI and magnetic resonance spectroscopy for the development of non-invasive biomarkers of disease progression, clarify the timing of pathological feature presentation in this model, and contribute to the validation of the TgF344-AD rat as a highly relevant model for pre-clinical Alzheimer’s disease research.
Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this paper , the TgF344-AD rat model was used for pre-clinical Alzheimer's disease diagnosis and identification of potential biomarkers, and longitudinal MRI and magnetic resonance spectroscopy (MRI) and behavioural testing was performed at 4, 10, 16, and 18 months.
Journal ArticleDOI
Brain Macro-Structural Alterations in Aging Rats: A Longitudinal Lifetime Approach
S. Gull,Christian Gaser,Karl-Heinz Herrmann,Anja Urbach,M. A. Boehme,Samia Afzal,Jürgen R. Reichenbach,Otto W. Witte,V. Schmidt +8 more
TL;DR: In this article , the authors longitudinally screened the brains of male RccHan:WIST rats for structural changes across their average lifespan and observed an increase in their global brain volume that was superimposed by divergent local morphologic alterations, with the largest aging effects in early and middle life.
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A Stereological Study of the Three Types of Ganglia of Male, Female, and Undifferentiated Scrobicularia plana (Bivalvia)
Sukanlaya Tantiwisawaruji,Maria João Rocha,Ana Silva,Miguel A. Pardal,Uthaiwan Kovitvadhi,Eduardo Rocha +5 more
TL;DR: New fundamental data can help interpret bivalve neurophysiology and make us wonder about the intricate and integrative neural networks of bivalves and how they relate to unsolved issues, such as nociception.
References
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R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Fitting Linear Mixed-Effects Models Using lme4
TL;DR: In this article, a model is described in an lmer call by a formula, in this case including both fixed-and random-effects terms, and the formula and data together determine a numerical representation of the model from which the profiled deviance or the profeatured REML criterion can be evaluated as a function of some of model parameters.
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lmerTest Package: Tests in Linear Mixed Effects Models
TL;DR: The lmerTest package extends the 'lmerMod' class of the lme4 package, by overloading the anova and summary functions by providing p values for tests for fixed effects, and implementing the Satterthwaite's method for approximating degrees of freedom for the t and F tests.