Journal ArticleDOI
Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human.
Jay A. Tischfield,Yu-Rong Xia,Diana M. Shih,Ivana Klisak,Ju Chen,Sandra J. Engle,Aristotle N. Siakotos,Michelle V. Winstead,Jeffrey J. Seilhamer,Valérie Allamand,Gabor Gyapay,Aldons J. Lusis +11 more
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TLDR
It is demonstrated in human that the homologous mouse loci are tightly linked and map to chromosome 1p34-p36.1, and unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.About:
This article is published in Genomics.The article was published on 1996-03-15. It has received 101 citations till now. The article focuses on the topics: Gene cluster & Chromosome 4.read more
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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
David A. Six,Edward A. Dennis +1 more
TL;DR: This review updates the classification of the various PLA(2)'s now described in the literature, and expands or realignment of Groups VI, VII and VIII, as well as the addition of Group XIPLA(2) from plants.
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The growing phospholipase A2 superfamily of signal transduction enzymes
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Recent progress in phospholipase A₂ research: from cells to animals to humans.
Makoto Murakami,Yoshitaka Taketomi,Yoshimi Miki,Hiroyasu Sato,Tetsuya Hirabayashi,Kei Yamamoto +5 more
TL;DR: This review focuses on current understanding of the emerging biological functions of PLA₂s and related enzymes, which evolved along with eicosanoid receptors when vertebrates first appeared.
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Receptors for a growing family of secreted phospholipases A2.
Gérard Lambeau,Michel Lazdunski +1 more
TL;DR: The increasing number of mammalian s PLA2s and the recent identification of different membrane proteins that bind sPLA2s makes it likely that these enzymes also behave as ligands for receptors, and that their physiological function is not limited to their catalytic activity.
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The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2.
Makoto Murakami,Satoko Shimbara,Terumi Kambe,Hiroshi Kuwata,Michelle V. Winstead,Jay A. Tischfield,Kudo Ichiro,Kudo Ichiro +7 more
TL;DR: This article examined the relative contributions of five distinct mammalian phospholipase A2(PLA2) enzymes (cytosolic PLA2(cPLA2; type IV), secretory PLA2s (sPLA2s; types IIA, V, and IIC), and Ca2+-independent PLA2 (iPLA2, type VI) to arachidonic acid (AA) metabolism by overexpressing them in human embryonic kidney 293 fibroblasts and Chinese hamster ovary cells.