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Macrophages and microglia in the nervous system
V. Hugh Perry,Siamon Gordon +1 more
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TLDR
The possible functions of resident and recruited macrophages in the developing and adult nervous system are reviewed and what contribution these cells might make to repair mechanisms in the central and peripheral nervous systems are examined.About:
This article is published in Trends in Neurosciences.The article was published on 1988-01-01. It has received 745 citations till now. The article focuses on the topics: Microglia & Nervous system.read more
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Interactions between lymphocytes, macrophages, and central nervous system cells.
TL;DR: The present review will highlight the multidirectional communication network, based on adhesion molecule expression and cytokine production, which appears in such situations between infiltrated leukocytes, brain microvessel endothelial cells, macroglia, microglial cells and neurons.
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A comparison of leucocyte responses to heat‐killed bacillus Calmette‐Guérin in different CNS compartments
M. K. Matyszak,V.H. Perry +1 more
TL;DR: The initial leucocyte response in the CNS parenchyma, ventricles and skin is compared to gain insight into the mechanisms by which the DTH responded to and the failure of the immune system to recognize foreign antigens sequestrated in the central nervous system may have significant implications.
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Suppression of nitric oxide formation by tyrosine kinase inhibitors in murine N9 microglia
TL;DR: The present results suggest that the co‐ordinated activation of protein tyrosine kinases/phosphatases, and proximal signalling events implicating the interplay between serine‐threonine kinase/ph phosphatase, is intricately linked with inflammatory mediated mechanisms of iNOS activation in microglial cells by regulating the activation of the transcription factor NFκB.
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Monoclonal antibodies to keratan sulfate immunolocalize ramified microglia in paraffin and cryostat sections of rat brain.
TL;DR: Six monoclonal antibodies recognizing epitopes within keratan sulfate (KS) chains are proposed as immunohistochemical markers for ramified microglia in both paraffin and cryostat sections of adult rat brain.
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Activation of microglial and endothelial cells in the rat brain after treatment with interferon‐gamma in vivo
TL;DR: It is shown for the first time that microglial cells proliferate inside the brain in response to a circulating cytokine.
References
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Book
Handbook of experimental immunology
TL;DR: This document describes the development and application of various methods for immunologic studies using monoclonal antibodies, a type of antibody, and some of the methods used in these studies are currently in use.
Journal ArticleDOI
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
Scott Koenig,Howard E. Gendelman,Jan M. Orenstein,Mauro C. Dal Canto,Gholam H. Pezeshkpour,Margaret Yungbluth,Frank Janotta,Allen J. Aksamit,Malcolm A. Martin,Anthony S. Fauci +9 more
TL;DR: The identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals and these cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients.
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F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Jonathan M. Austyn,Siamon Gordon +1 more
TL;DR: Immunoprecipitation experiments demonstrated that the antigen F4/80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.
Journal ArticleDOI
The AIDS dementia complex: II. Neuropathology
TL;DR: The AIDS dementia complex is established as a distinct clinical and pathological entity and, together with accumulating virological evidence, suggests that it is caused by direct LAV/HTLV‐III brain infection.