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Macrophages and microglia in the nervous system
V. Hugh Perry,Siamon Gordon +1 more
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TLDR
The possible functions of resident and recruited macrophages in the developing and adult nervous system are reviewed and what contribution these cells might make to repair mechanisms in the central and peripheral nervous systems are examined.About:
This article is published in Trends in Neurosciences.The article was published on 1988-01-01. It has received 745 citations till now. The article focuses on the topics: Microglia & Nervous system.read more
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The origin and differentiation of microglial cells during development.
TL;DR: The factors that control the invasion of the nervous parenchyma, migration within the developing CNS and differentiation of microglial cells are not well known, and these phenomena apparently depend on environmental factors such as soluble or cell-surface bound molecules and components of the extracellular matrix.
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Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS.
TL;DR: In the final phases of HIV or SIV infection, this chronic, widespread, and dramatic level of macrophage/monocyte/microglial activation constitutes a self-sustaining state of Macrophage dysregulation, which results in pathological alterations and the emergence of various neurological problems.
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Immunocytochemical study of an early microglial activation in ischemia.
TL;DR: The microglial reaction would seem to be an early, sensitive, and reliable marker for the occurrence of neuronal damage in ischemia.
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ATP-mediated cytotoxicity in microglial cells.
Davide Ferrari,Paola Chiozzi,Simonetta Falzoni,Monica Dal Susino,Ginetta Collo,G. Buell,Francesco Di Virgilio +6 more
TL;DR: Morphological and biochemical analysis suggests that ATP-dependent cell death in microglial cells occurs by apoptosis and release ATP via a non-lytic mechanism when activated by bacterial endotoxin, thus suggesting the operation of a purinergic autocrine/paracrine loop.
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Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro
Solon Thanos,Jörg Mey,M Wild +2 more
TL;DR: It is demonstrated that axotomy initializes a cascade of microglia-mediated autodestructive retinal responses, which culminate in degradation of “sick,” but obviously viable neurons, and postulate that the retinal microglial system has a key role in recognizing and eliminating severed neurons.
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Book
Handbook of experimental immunology
TL;DR: This document describes the development and application of various methods for immunologic studies using monoclonal antibodies, a type of antibody, and some of the methods used in these studies are currently in use.
Journal ArticleDOI
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
Scott Koenig,Howard E. Gendelman,Jan M. Orenstein,Mauro C. Dal Canto,Gholam H. Pezeshkpour,Margaret Yungbluth,Frank Janotta,Allen J. Aksamit,Malcolm A. Martin,Anthony S. Fauci +9 more
TL;DR: The identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals and these cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients.
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F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Jonathan M. Austyn,Siamon Gordon +1 more
TL;DR: Immunoprecipitation experiments demonstrated that the antigen F4/80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.
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The AIDS dementia complex: II. Neuropathology
TL;DR: The AIDS dementia complex is established as a distinct clinical and pathological entity and, together with accumulating virological evidence, suggests that it is caused by direct LAV/HTLV‐III brain infection.