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Macrophages and microglia in the nervous system
V. Hugh Perry,Siamon Gordon +1 more
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TLDR
The possible functions of resident and recruited macrophages in the developing and adult nervous system are reviewed and what contribution these cells might make to repair mechanisms in the central and peripheral nervous systems are examined.About:
This article is published in Trends in Neurosciences.The article was published on 1988-01-01. It has received 745 citations till now. The article focuses on the topics: Microglia & Nervous system.read more
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Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica
Kyeong Wan Woo,Eunjung Moon,Oh Wook Kwon,Sung Ok Lee,Sun Yeou Kim,Sang Zin Choi,Mi Won Son,Kang Ro Lee +7 more
TL;DR: Two new cyclic diarylheptanoids, diosniponol A and B, together with 10 known compounds were isolated from the rhizomes of Dioscorea nipponica, and showed potent inhibitory activities on NO production without cell toxicity in lipopolysaccharide-activated BV-2 cells.
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Macrophage-like cells in the presumptive optic pathways in the floor of the diencephalon of the chick embryo.
TL;DR: M morphological evidence of macrophage-like cells within the suboptic necrotic centres of the chick embryo diencephalon floor and mesenchymal cells with morphological features similar to these cells in the process of traversing the neuroepithelium from the mesenchyme compartment toward the ventricular lumen are reported, suggesting that the intraventricular macrophages arise from the MesenchYme underlying the diencecephalon floor.
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Characterization of the dynamic nature of microglial cells
TL;DR: Dynamic properties of ramified microglia appear to possess a unique and highly dynamic nature, and this feature is proposed as a potential marker for these cells.
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Phosphatidylserine-Containing Liposomes: Potential Pharmacological Interventions Against Inflammatory and Immune Diseases Through the Production of Prostaglandin E2 After Uptake by Myeloid Derived Phagocytes
Zhou Wu,Hiroshi Nakanishi +1 more
TL;DR: PS-containing liposomes (PSLs) will be potential pharmacological interventions for inflammatory and immune diseases through feedback mechanism utilizing PGE2.
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Lipopolysaccharide stimulates differential expression of myristoylated protein kinase C substrates in murine microglia.
TL;DR: This work has investigated LPS‐mediated changes in two myristoylated substrates of protein kinase C (PKC): MARCKS and MRP, apparently independent of TNFα or CSF‐1.
References
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Book
Handbook of experimental immunology
TL;DR: This document describes the development and application of various methods for immunologic studies using monoclonal antibodies, a type of antibody, and some of the methods used in these studies are currently in use.
Journal ArticleDOI
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
Scott Koenig,Howard E. Gendelman,Jan M. Orenstein,Mauro C. Dal Canto,Gholam H. Pezeshkpour,Margaret Yungbluth,Frank Janotta,Allen J. Aksamit,Malcolm A. Martin,Anthony S. Fauci +9 more
TL;DR: The identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals and these cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients.
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F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Jonathan M. Austyn,Siamon Gordon +1 more
TL;DR: Immunoprecipitation experiments demonstrated that the antigen F4/80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.
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The AIDS dementia complex: II. Neuropathology
TL;DR: The AIDS dementia complex is established as a distinct clinical and pathological entity and, together with accumulating virological evidence, suggests that it is caused by direct LAV/HTLV‐III brain infection.