Journal ArticleDOI
Macrophages and microglia in the nervous system
V. Hugh Perry,Siamon Gordon +1 more
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TLDR
The possible functions of resident and recruited macrophages in the developing and adult nervous system are reviewed and what contribution these cells might make to repair mechanisms in the central and peripheral nervous systems are examined.About:
This article is published in Trends in Neurosciences.The article was published on 1988-01-01. It has received 745 citations till now. The article focuses on the topics: Microglia & Nervous system.read more
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Book ChapterDOI
Colonisation of the human central nervous system by microglia: the roles of chemokines and vascular adhesion molecules.
David Male,Payam Rezaie +1 more
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Microglial responses to physiological change: osmotic stress elevates DNA synthesis of neurohypophyseal microglia.
TL;DR: Neurohypophyseal microglia respond to increased neurosecretory activity during the adaptation to osmotic stress in a distinctive way which differs from microglial reactions to inflammatory stimuli elsewhere in the CNS.
Journal ArticleDOI
Inhibition of carbonic anhydrase IX in glioblastoma multiforme.
Abdolali Amiri,Phuong Uyen Le,Alexandre Moquin,Gayane Machkalyan,Kevin Petrecca,John W. Gillard,Nathan Yoganathan,Dusica Maysinger +7 more
TL;DR: Cell death of human glioblastoma spheroids and B TSC is significantly increased with combined treatment after 7 days, and the effectiveness of ATZ is significantly enhanced against BTSC and U251N when incorporated into nano-carriers point toward the usefulness of nano-delivery of CAIX inhibitors and their combination with chemotherapeutics for gliOBlastoma treatment.
Journal ArticleDOI
Ultrastructural changes in the gracile nucleus of the rat after sciatic nerve transection.
TL;DR: The results clearly show that various types of degenerative changes occur in the gracile nucleus after peripheral nerve injury, which differ markedly from previously described transganglionic changes in other systems.
Journal ArticleDOI
Contact-Spacing Among Astrocytes is Independent of Neighbouring Structures: In Vivo and In Vitro Evidence
TL;DR: It is suggested that the cell‐cell interactions involved in contact spacing serve to distribute astrocytes through the central nervous system, and may, in other tissues, underlie the formation of epithelia.
References
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Book
Handbook of experimental immunology
TL;DR: This document describes the development and application of various methods for immunologic studies using monoclonal antibodies, a type of antibody, and some of the methods used in these studies are currently in use.
Journal ArticleDOI
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
Scott Koenig,Howard E. Gendelman,Jan M. Orenstein,Mauro C. Dal Canto,Gholam H. Pezeshkpour,Margaret Yungbluth,Frank Janotta,Allen J. Aksamit,Malcolm A. Martin,Anthony S. Fauci +9 more
TL;DR: The identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals and these cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients.
Journal ArticleDOI
F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Jonathan M. Austyn,Siamon Gordon +1 more
TL;DR: Immunoprecipitation experiments demonstrated that the antigen F4/80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.
Journal ArticleDOI
The AIDS dementia complex: II. Neuropathology
TL;DR: The AIDS dementia complex is established as a distinct clinical and pathological entity and, together with accumulating virological evidence, suggests that it is caused by direct LAV/HTLV‐III brain infection.