Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
Jonas Lötscher,Adrià-Arnau Martí I Líndez,Nicole Kirchhammer,Elisabetta Cribioli,Greta A Giordano,Marcel P. Trefny,Markus Lenz,Sacha I. Rothschild,Paolo Strati,Marco Künzli,Claudia. Lotter,Susanne H. Schenk,Philippe Dehio,Jordan Löliger,Ludivine C. Litzler,David Schreiner,Victoria Koch,Nicolas Page,Da-Youn Lee,Jasmin Grählert,Dmitry Kuzmin,Anne-Valérie Burgener,Doron Merkler,Miklos Pless,Maria L. Balmer,Walter Reith,Jörg Huwyler,Melita Irving,Carolyn G. King,Alfred Zippelius,Christoph Hess +30 more
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TLDR
In this article , the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8+ T cells, thereby augmenting calcium flux, signal transduction, metabolic reprogramming, immune synapse formation, and specific cytotoxicity.About:
This article is published in Cell.The article was published on 2022-01-01 and is currently open access. It has received 51 citations till now. The article focuses on the topics: Medicine & Biology.read more
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Research advances of magnesium and magnesium alloys worldwide in 2021
TL;DR: More than 4000 papers in the field of Mg and Mg alloys were published and indexed in Web of Science (WoS) Core Collection database in 2019 as discussed by the authors , which indicated that the microstructure, mechanical properties, and corrosion were the main research focus.
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Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment
TL;DR: Combination immunotherapy can help overcome resistance to immune checkpoint inhibitors as mentioned in this paper , however, resistance to ICB occurs frequently due to tumor-intrinsic alterations or extrinsic factors in the tumor microenvironment.
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PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy
Zeyu Xiao,Duo Wang,Chan Wang,Zerong Chen,Cuiqing Huang,Yuan Yang,Lin Xie,Lu-lu Zhang,Lingling Xu,Kuan Hu,Zhou Li,Liangping Luo +11 more
TL;DR: In this article , a ternary hydrogel composed of polyvinyl alcohol (PVA), polyethylenimine (PEI), and magnesium ions was used to upregulate PD-L1 expression and promote M1-like macrophage polarization.
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New anti-cancer explorations based on metal ions
TL;DR: In this article , the new applications of metal ions in cancer have attracted increasing attention, such as interfering with osmotic pressure, triggering biocatalysis, activating immune pathways, and generating the prooxidant effect.
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Immunomodulation Effect of Biomaterials on Bone Formation
TL;DR: This review combines advances in bone immunology with biomaterial immunomodulatory properties to provide an overview of biomaterials-mediated immune responses to regulate bone regeneration, as well as methods to assess the bone immunommodulatory properties of bone biomaterial's and how these strategies can be used for future bone tissue engineering applications.
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Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
Sattva S. Neelapu,Frederick L. Locke,Nancy L. Bartlett,Lazaros J. Lekakis,David B. Miklos,Caron A. Jacobson,Ira Braunschweig,Olalekan O. Oluwole,Tanya Siddiqi,Yi Lin,John M. Timmerman,Patrick J. Stiff,Jonathan W. Friedberg,Ian W. Flinn,Andre Goy,Brian T. Hill,Mitchell R. Smith,Abhinav Deol,Umar Farooq,Peter A. McSweeney,Javier Munoz,Irit Avivi,Januario E. Castro,Jason R. Westin,Julio C. Chavez,Armin Ghobadi,Krishna V. Komanduri,Ronald Levy,Eric D. Jacobsen,Thomas E. Witzig,Patrick M. Reagan,Adrian Bot,John J. Rossi,Lynn Navale,Yizhou Jiang,Jeff Aycock,Meg Elias,David Z. Chang,Jeff Wiezorek,William Y. Go +39 more
TL;DR: Patients with refractory large B‐cell lymphoma who received CAR T‐cell therapy with axi‐cel had high levels of durable response, with a safety profile that included myelosuppression, the cytokine release syndrome, and neurologic events.
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Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes
Mark E. Dudley,John R. Wunderlich,Paul F. Robbins,James Chih-Hsin Yang,Patrick Hwu,Douglas J. Schwartzentruber,Suzanne L. Topalian,Richard M. Sherry,Nicholas P. Restifo,Amy M. Hubicki,Michael R. Robinson,Mark Raffeld,Paul H. Duray,Claudia A. Seipp,Linda Rogers-Freezer,Kathleen E. Morton,Sharon Mavroukakis,Donald E. White,Steven A. Rosenberg +18 more
TL;DR: The adoptive transfer of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen resulted in the persistent clonal repopulation of T cells in cancer patients, leading to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction.
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Henry Heberle,Gabriela Vaz Meirelles,Felipe Rodrigues da Silva,Guilherme P. Telles,Rosane Minghim +4 more
TL;DR: InteractiVenn is a more flexible tool for interacting with Venn diagrams including up to six sets that offers a clean interface for Venn diagram construction and enables analysis of set unions while preserving the shape of the diagram.
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Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial
Frederick L. Locke,Armin Ghobadi,Caron A. Jacobson,David B. Miklos,Lazaros J. Lekakis,Olalekan O. Oluwole,Yi Lin,Ira Braunschweig,Brian T. Hill,John M. Timmerman,Abhinav Deol,Patrick M. Reagan,Patrick J. Stiff,Ian W. Flinn,Umar Farooq,Andre Goy,Peter A. McSweeney,Javier Munoz,Tanya Siddiqi,Julio C. Chavez,Alex F. Herrera,Nancy L. Bartlett,Jeffrey S. Wiezorek,Lynn Navale,Allen Xue,Yizhou Jiang,Adrian Bot,John M. Rossi,Jenny J. Kim,William Y. Go,Sattva S. Neelapu +30 more
TL;DR: Long-term activity and safety outcomes of the ZUMA-1 study suggest that axicabtagene ciloleucel can induce durable responses and a median overall survival of greater than 2 years, and has a manageable relapsed or refractory disease or relapsed after autologous stem-cell transplantation.
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Magnesium. An update on physiological, clinical and analytical aspects.
TL;DR: The improved procedures for the assay of different magnesium states are useful in understanding the role of magnesium in health and disease.