Journal ArticleDOI
Male infertility due to asthenozoospermia and flagellar anomaly: detection in routine semen analysis.
D. Marmor,F. Grob-Menendez +1 more
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TLDR
Major monomorphous teratozoospermia, due to sperm tail structural anomalies, were detected in 42 out of 4231 infertile patients during routine semen analysis, and were always associated with poor forward motility, while mobility and penetration into human cervical mucus were sometimes impaired only partially.Abstract:
Summary
Major monomorphous teratozoospermia, due to sperm tail structural anomalies, were detected in 42 out of 4231 infertile patients during routine semen analysis. The flagella were very short or absent in 16 cases, shortened with thickness irregularity in 18 cases, and of normal length with diameter anomalies in eight cases. These syndromes were always associated with poor forward motility, while mobility and penetration into human cervical mucus were sometimes impaired only partially. With good sperm smears and an experienced observer, the diagnosis could be made without the need for electron microscopic analysis. All the affected patients were sterile and several syndromes could have been transmitted genetically.read more
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Journal ArticleDOI
Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.
Mariem Ben Khelifa,Mariem Ben Khelifa,Mariem Ben Khelifa,Charles Coutton,Charles Coutton,Raoudha Zouari,Thomas Karaouzène,Thomas Karaouzène,John Rendu,John Rendu,Marie Bidart,Marie Bidart,Sandra Yassine,Sandra Yassine,Virginie Pierre,Virginie Pierre,Julie Delaroche,Julie Delaroche,Sylviane Hennebicq,Sylviane Hennebicq,Didier Grunwald,Didier Grunwald,Denise Escalier,Karine Pernet-Gallay,Karine Pernet-Gallay,Pierre-Simon Jouk,Nicolas Thierry-Mieg,Aminata Touré,Aminata Touré,Aminata Touré,Christophe Arnoult,Christophe Arnoult,Pierre F. Ray,Pierre F. Ray +33 more
TL;DR: Infertility was the only symptom of primary ciliary dyskinesia observed in affected subjects, suggesting that DNAH1 function in cilium is not as critical as in sperm flagellum, and genetic etiology is likely in most cases.
Journal ArticleDOI
Immunohistochemical detection of immature Sertoli cell markers in testicular tissue of infertile adult men : a preliminary study
TL;DR: Co-expression of AMH and cytokeratin suggests that spermatogenic impairment such as sperMatogenic arrest and SCO syndrome in human seminiferous tubules is associated with a population of Sertoli cells showing a prepubertal stage of development.
Journal ArticleDOI
The Small Heat Shock Protein ODF1/HSPB10 Is Essential for Tight Linkage of Sperm Head to Tail and Male Fertility in Mice
Kefei Yang,Andreas Meinhardt,Bing Zhang,Paweł Grzmil,Paweł Grzmil,Ibrahim M. Adham,Sigrid Hoyer-Fender +6 more
TL;DR: The results suggest that ODF1, besides being involved in the correct arrangement of mitochondrial sheath and outer dense fibers, is essential for rigid junction of sperm head and tail, and might account for some of the cases of human infertility with decapitated sperm heads.
Journal ArticleDOI
A homozygous CEP135 mutation is associated with multiple morphological abnormalities of the sperm flagella (MMAF).
TL;DR: The case of a 30-year-old infertile male from a consanguineous family is reported, marking the first report of a homozygous mutation of CEP135 associated with MMAF and will help predict and assess pregnancy outcomes associated with in vitro fertilization.
Journal ArticleDOI
Effect of cigarette smoke on DNA damage, oxidative stress, and morphological alterations in mouse testis and spermatozoa
TL;DR: The findings suggest that involuntary smoking is potentially able to impair fertility in subjects exposed early in life, as compared with sham-exposed mice.
References
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Journal ArticleDOI
The ultrastructural pathology of the spermatozoon as a cause of infertility: the role of electron microscopy in the evaluation of semen quality.
TL;DR: Revue selective de la pathologie subcellulaire des spermatozoides humains et analyse de son action limitante sur la fertilite, insiste sur l'importance clinique de l'examen ultrastructural du sperme.
Journal ArticleDOI
Dysplasia of the fibrous sheath: an ultrastructural defect of human spermatozoa associated with sperm immotility and primary sterility.
TL;DR: In this article, a study of a group of five patients presenting with primary sterility and showing severe sperm immotility is presented, and the existence of a common ultrastructural defect affecting most spermatozoa, its presence in two brothers and the possibility of association with immotile respiratory cilia point to the existence a syndrome (namely the "dysplasia of the fibrous sheath") of possible familial transmission.
Journal ArticleDOI
Flagellar mutants in man: on the heterogeneity of the immotile-cilia syndrome.
Björn A. Afzelius,Rune Eliasson +1 more
TL;DR: 14 cases of sperm tails from men who have spermatozoa that are immotile but living are described, which belong to five distinct groups and three men from this fifth category did not suffer from the immotiles-cilia syndrome.
Journal ArticleDOI
Pathology of the cytoskeleton of the human sperm flagellum: axonemal and peri-axonemal anomalies.
D. Escalier,G. David +1 more
TL;DR: The various light microscopic characteristics of each of the 6 groups of anomalies represented 6 seminal profiles which should permit their detection during a routine semen analysis and would suggest some morphogenetic links between them.