Measuring the thickness of the human cerebral cortex from magnetic resonance images
Bruce Fischl,Anders M. Dale +1 more
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TLDR
An automated method for accurately measuring the thickness of the cerebral cortex across the entire brain and for generating cross-subject statistics in a coordinate system based on cortical anatomy is presented.Abstract:
Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders. Manual methods for estimating cortical thickness from neuroimaging data are labor intensive, requiring several days of effort by a trained anatomist. Furthermore, the highly folded nature of the cortex is problematic for manual techniques, frequently resulting in measurement errors in regions in which the cortical surface is not perpendicular to any of the cardinal axes. As a consequence, it has been impractical to obtain accurate thickness estimates for the entire cortex in individual subjects, or group statistics for patient or control populations. Here, we present an automated method for accurately measuring the thickness of the cerebral cortex across the entire brain and for generating cross-subject statistics in a coordinate system based on cortical anatomy. The intersubject standard deviation of the thickness measures is shown to be less than 0.5 mm, implying the ability to detect focal atrophy in small populations or even individual subjects. The reliability and accuracy of this new method are assessed by within-subject test-retest studies, as well as by comparison of cross-subject regional thickness measures with published values.read more
Citations
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Cortical thickness in first-episode schizophrenia patients and individuals at high familial risk: a cross-sectional comparison.
Emma Sprooten,Emma Sprooten,Emma Sprooten,Martina Papmeyer,Annya M. Smyth,Daniel Vincenz,Daniel Vincenz,Sibylle Honold,Sibylle Honold,Guy A. Conlon,Guy A. Conlon,T. William J. Moorhead,Dominic Job,Heather C. Whalley,Jeremy Hall,Andrew M. McIntosh,David C.G. Owens,Eve C. Johnstone,Stephen M. Lawrie +18 more
TL;DR: Findings confirm cortical thickness reductions in schizophrenia patients that increased familial risk for schizophrenia is associated with thinning in the left middle temporal lobe, irrespective of subsequent disease onset.
Journal ArticleDOI
Abnormal gray matter aging in chronic pain patients
Massieh Moayedi,Irit Weissman-Fogel,Tim V. Salomons,Adrian P. Crawley,Adrian P. Crawley,Michael B. Goldberg,Michael B. Goldberg,Bruce V. Freeman,Bruce V. Freeman,Howard C. Tenenbaum,Howard C. Tenenbaum,Karen D. Davis +11 more
TL;DR: This study is the first to show that chronic pain is associated with abnormal GM aging in focal cortical regions associated with pain and motor processes and that patients have accelerated whole brain GM atrophy.
Journal ArticleDOI
Sex-Related Differences of Cortical Thickness in Patients with Chronic Abdominal Pain
Zhiguo Jiang,Zhiguo Jiang,Zhiguo Jiang,Ivo D. Dinov,Ivo D. Dinov,Jennifer S. Labus,Yonggang Shi,Alen Zamanyan,Arpana Gupta,Cody Ashe-McNalley,Jui-Yang Hong,Kirsten Tillisch,Arthur W. Toga,Emeran A. Mayer +13 more
TL;DR: While IBS as a group did not show significant differences in CT compared to HCs, sex related differences were observed both within the IBS and the HC groups, and several measures of IBS symptom severity showed significant correlation with CT changes in female IBS patients.
Journal ArticleDOI
Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging.
Koji Kamagata,Andrew Zalesky,Taku Hatano,Ryo Ueda,Maria A Di Biase,Ayami Okuzumi,Keigo Shimoji,Masaaki Hori,Karen Caeyenberghs,Christos Pantelis,Nobutaka Hattori,Shigeki Aoki +11 more
TL;DR: DKI and NODDI can detect cerebral GM abnormalities in PD in a more sensitive manner when compared with conventional methods, and may be useful for the diagnosis of PD and assessment of motor deficits.
Journal ArticleDOI
Structural brain alterations in primary open angle glaucoma: a 3T MRI study
Jieqiong Wang,Ting-ting Li,Bernhard A. Sabel,Zhiqiang Chen,Hongwei Wen,Jianhong Li,Xiaobin Xie,Diya Yang,Weiwei Chen,Ningli Wang,Junfang Xian,Huiguang He +11 more
TL;DR: It is demonstrated that POAG affects both vision-related structures and non-visual cortical regions and alterations of the brain visual structures reflect the clinical severity of glaucoma.
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