Measuring the thickness of the human cerebral cortex from magnetic resonance images
Bruce Fischl,Anders M. Dale +1 more
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TLDR
An automated method for accurately measuring the thickness of the cerebral cortex across the entire brain and for generating cross-subject statistics in a coordinate system based on cortical anatomy is presented.Abstract:
Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders. Manual methods for estimating cortical thickness from neuroimaging data are labor intensive, requiring several days of effort by a trained anatomist. Furthermore, the highly folded nature of the cortex is problematic for manual techniques, frequently resulting in measurement errors in regions in which the cortical surface is not perpendicular to any of the cardinal axes. As a consequence, it has been impractical to obtain accurate thickness estimates for the entire cortex in individual subjects, or group statistics for patient or control populations. Here, we present an automated method for accurately measuring the thickness of the cerebral cortex across the entire brain and for generating cross-subject statistics in a coordinate system based on cortical anatomy. The intersubject standard deviation of the thickness measures is shown to be less than 0.5 mm, implying the ability to detect focal atrophy in small populations or even individual subjects. The reliability and accuracy of this new method are assessed by within-subject test-retest studies, as well as by comparison of cross-subject regional thickness measures with published values.read more
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Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortex.
TL;DR: The present results suggest that the spatial resolution of the EEG cortical source imaging can correctly discriminate cortical activation changes in V1 corresponding to less than 3 degrees visual field changes.
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Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study
Sean N. Hatton,Jim Lagopoulos,Daniel F. Hermens,Sharon L. Naismith,Max R. Bennett,Ian B. Hickie +5 more
TL;DR: It is demonstrated that insula GMV changes are associated with neurocognitive deficits and clinical symptoms in such young patients, including depression, anxiety, bipolar and psychosis patients together.
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Bipolar II disorder is associated with thinning of prefrontal and temporal cortices involved in affect regulation
Torbjørn Elvsåshagen,Torbjørn Elvsåshagen,Lars T. Westlye,Lars T. Westlye,Erlend Bøen,Erlend Bøen,Per Kristian Hol,Ole A. Andreassen,Ole A. Andreassen,Birgitte Boye,Ulrik Fredrik Malt,Ulrik Fredrik Malt +11 more
TL;DR: Comparing magnetic resonance imaging‐based indices of cortical thickness and surface area between individuals with BD‐II and healthy controls is compared.
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Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK Biobank.
Emma Neilson,Xueyi Shen,Simon R. Cox,Toni-Kim Clarke,Eleanor M. Wigmore,Jude Gibson,David M. Howard,Mark Adams,Harris Ma,Gail Davies,Ian J. Deary,Heather C. Whalley,Andrew M. McIntosh,Stephen M. Lawrie +13 more
TL;DR: Results suggest that individual differences in CT are partly influenced by genetic variants and are most likely not due to factors downstream of disease onset, and may help to elucidate the genetic pathophysiology of schizophrenia.
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Structural and functional changes across the visual cortex of a patient with visual form agnosia
Holly Bridge,Owen Thomas,Loredana Minini,Cristiana Cavina-Pratesi,A. D. Milner,Andrew Parker +5 more
TL;DR: It is concluded that it is not possible to understand fully the deficits in object perception in visual-form agnosia without the exploitation of both structural and functional measurements.
References
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Numerical recipes in C
TL;DR: The Diskette v 2.06, 3.5''[1.44M] for IBM PC, PS/2 and compatibles [DOS] Reference Record created on 2004-09-07, modified on 2016-08-08.
Journal ArticleDOI
Snakes : Active Contour Models
TL;DR: This work uses snakes for interactive interpretation, in which user-imposed constraint forces guide the snake near features of interest, and uses scale-space continuation to enlarge the capture region surrounding a feature.
Journal ArticleDOI
Cortical surface-based analysis. I. Segmentation and surface reconstruction
TL;DR: A set of automated procedures for obtaining accurate reconstructions of the cortical surface are described, which have been applied to data from more than 100 subjects, requiring little or no manual intervention.
Book
Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging
TL;DR: Direct and Indirect Radiologic Localization Reference System: Basal Brain Line CA-CP Cerebral Structures in Three-Dimensional Space Practical Examples for the Use of the Atlas in Neuroradiologic Examinations Three- Dimensional Atlas of a Human Brain Nomenclature-Abbreviations Anatomic Index Conclusions.