Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Daniel J. Antoine,James W. Dear,Philip J. Starkey Lewis,Vivien Platt,Judy Coyle,Moyra Masson,Ruben Thanacoody,Alasdair Gray,David J. Webb,Jonathan G. Moggs,D. Nicholas Bateman,Christopher E. Goldring,B. Kevin Park +12 more
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Elevations in plasma miR‐122, HMGB1, and necrosis K18 identified subsequent ALI development in patients on admission to the hospital, soon after acetaminophen overdose, and in patients with ALTs in the normal range.About:
This article is published in Hepatology.The article was published on 2013-08-01 and is currently open access. It has received 374 citations till now. The article focuses on the topics: acetaminophen overdose & Alanine transaminase.read more
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Book ChapterDOI
Clinical Application of MicroRNAs in Liver Diseases
Guisheng Song,H. Vollbrecht +1 more
TL;DR: There is an urgent need for noninvasive markers to improve diagnostics and prognostic ability in liver pathology and develop novel therapeutic agents for liver disorders.
Journal ArticleDOI
The Key Molecular Mechanisms of Sini Decoction Plus Ginseng Soup to Rescue Acute Liver Failure: Regulating PPARα to Reduce Hepatocyte Necroptosis?
TL;DR: The potential therapeutic effect of SNRS on ALF may be through promoting the expression of PPARα and increasing the level of ATP in liver tissue, thereby inhibiting necroptosis of hepatocytes, reducing hepatocyte damage, and improving liver function.
Posted ContentDOI
Biomarker evaluation of plasma microRNA-122, high-mobility group box-1 and keratin-18 in acute gallstone disease
TL;DR: Plasma miRNA-122 and keratin-18 plasma concentrations are elevated in patients with gallstones, however, these biomarkers were not sufficiently discriminatory to be progressed as clinically useful biomarkers in this context.
Book ChapterDOI
Detection of Hepatotoxicity in Clinical and Experimental Settings
TL;DR: Both established and emerging tests for the detection of hepatotoxicity in mammalian test species and in clinical practice are discussed.
Book ChapterDOI
In silico prediction of drug-induced liver injury: Quo vadis?
Ching-Feng Weng,Max K. Leong +1 more
TL;DR: A number of DILI predictive models in every aspect are briefly described, and efforts to develop in silico models to predict hepatotoxicity in the last decade are outlined.
References
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Journal ArticleDOI
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Tiziana Bonaldi,Fabio Talamo,Paola Scaffidi,Denise Ferrera,Annalisa Porto,Angela Bachi,Anna Rubartelli,Alessandra Agresti,Marco Bianchi +8 more
TL;DR: It is shown here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm, and secreted when monocytic cells receive an appropriate second signal.
Journal ArticleDOI
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Kai Wang,Shile Zhang,Bruz Marzolf,Pamela Troisch,Amy Brightman,Zhiyuan Hu,Leroy Hood,David J. Galas +7 more
TL;DR: It is demonstrated that specific microRNA species, such as mir-122 and mir-192, both are enriched in the liver tissue and exhibit dose- and exposure duration-dependent changes in the plasma that parallel serum aminotransferase levels and the histopathology of liver degeneration, but their changes can be detected significantly earlier.
Journal ArticleDOI
Characterization of microRNA expression profiles in normal human tissues
TL;DR: A global view of tissue distribution of miRNAs in relation to their chromosomal locations and genomic structures is presented to support their tissue-specific functional roles to regulate the physiologies of the normal tissues in which they are expressed.
Journal ArticleDOI
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
TL;DR: The formation of oxidants and the defense mechanisms available for cells are addressed and knowledge is applied to better understand mechanisms of drug hepatotoxicity, especially acetaminophen-induced liver injury.
Journal ArticleDOI
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
Mitchell R. McGill,Matthew R. Sharpe,C. David Williams,Mohammad Taha,Steven C. Curry,Hartmut Jaeschke +5 more
TL;DR: It is suggested that mitochondrial damage and nuclear DNA fragmentation are likely to be critical events in APAP hepatotoxicity in humans, resulting in necrotic cell death.