Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Daniel J. Antoine,James W. Dear,Philip J. Starkey Lewis,Vivien Platt,Judy Coyle,Moyra Masson,Ruben Thanacoody,Alasdair Gray,David J. Webb,Jonathan G. Moggs,D. Nicholas Bateman,Christopher E. Goldring,B. Kevin Park +12 more
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TLDR
Elevations in plasma miR‐122, HMGB1, and necrosis K18 identified subsequent ALI development in patients on admission to the hospital, soon after acetaminophen overdose, and in patients with ALTs in the normal range.About:
This article is published in Hepatology.The article was published on 2013-08-01 and is currently open access. It has received 374 citations till now. The article focuses on the topics: acetaminophen overdose & Alanine transaminase.read more
Citations
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Can AST/ALT ratio indicate recovery after acute paracetamol poisoning? The authors reply.
TL;DR: It is suggested that the ratio of aspartate aminotransferase (AST) to alanine aminodiazepine (ALT) may be useful only in patients with elevated transaminase concentrations in the absence of other laboratory or clinical evidence of hepatic failure, and AST and ALT are not equivalent as their respective concentrations fall.
Journal ArticleDOI
On the Treatment of Acute Poisoning With Paracetamol
Anastasiya Yu. Simonova,M. M. Potskhveriya,M. V. Belova,K. K. Ilyashenko,V. V. Kulabuhov,N. Y. Stolbova,A. E. Klyuev +6 more
TL;DR: In 10 patients with a high risk of liver damage, who were treated with a 21-hour regimen of ACC administration, no hepatotoxic effect was found and its early use in the complex of treatment almost always prevents the development of acute liver failure.
Paracetamol overdose: Relevance of recent evidence for managing patients in Sri Lanka
Chris G Uragoda,Colvin Goonaratna,Anuruddha Abeygunasekera,Varuni de Silva Mbbs,B J C Perera,Shalini Sri Ranganathan,Malik Goonewardene,Renuka Jayatissa,Udaya K. Ranawaka,Arambepola Mbbs,Chandu de Silva Mbbs,Samath Dharmaratne,Tiran Dias,Ranil Fernando Frcs,Senaka Rajapakse,Sisira Siribaddana,David Lallo +16 more
TL;DR: This article focuses on some recent developments and discusses the relevance of the new evidence for managing patients in Sri Lanka with paracetamol overdose.
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Mathematical modelling and statistical analysis of indocyanine green and other biomarkers of hepatic function and drug-induced liver injury
Joseph Leedale,Chantelle L. Mason,Nathalie Brillant,Steven D. Webb,Steven D. Webb,James W. Dear +5 more
TL;DR: In this article, a combined system toxicology framework is proposed to evaluate the utility and translatability of these biomarkers, which is dependent on many factors such as practicality, invasiveness, cost, relevance and ease of use.
Dissertation
Chem-nat: a unique chemical approach for nucleic acids testing
TL;DR: In this article, a nuevo enfoque de NAT basado en un proceso de quimica dinamica and en el que se utilizan sondas de PNA abasicas (sondas DGL) and bases nitrogenadas modificadas with un grupo aldehido (SMART-Nucleobases, SMART-NBs), permite la “lectura” de acidos nucleicos con resolucion of una sola base.
References
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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Tiziana Bonaldi,Fabio Talamo,Paola Scaffidi,Denise Ferrera,Annalisa Porto,Angela Bachi,Anna Rubartelli,Alessandra Agresti,Marco Bianchi +8 more
TL;DR: It is shown here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm, and secreted when monocytic cells receive an appropriate second signal.
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Circulating microRNAs, potential biomarkers for drug-induced liver injury
Kai Wang,Shile Zhang,Bruz Marzolf,Pamela Troisch,Amy Brightman,Zhiyuan Hu,Leroy Hood,David J. Galas +7 more
TL;DR: It is demonstrated that specific microRNA species, such as mir-122 and mir-192, both are enriched in the liver tissue and exhibit dose- and exposure duration-dependent changes in the plasma that parallel serum aminotransferase levels and the histopathology of liver degeneration, but their changes can be detected significantly earlier.
Journal ArticleDOI
Characterization of microRNA expression profiles in normal human tissues
TL;DR: A global view of tissue distribution of miRNAs in relation to their chromosomal locations and genomic structures is presented to support their tissue-specific functional roles to regulate the physiologies of the normal tissues in which they are expressed.
Journal ArticleDOI
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
TL;DR: The formation of oxidants and the defense mechanisms available for cells are addressed and knowledge is applied to better understand mechanisms of drug hepatotoxicity, especially acetaminophen-induced liver injury.
Journal ArticleDOI
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
Mitchell R. McGill,Matthew R. Sharpe,C. David Williams,Mohammad Taha,Steven C. Curry,Hartmut Jaeschke +5 more
TL;DR: It is suggested that mitochondrial damage and nuclear DNA fragmentation are likely to be critical events in APAP hepatotoxicity in humans, resulting in necrotic cell death.