Journal ArticleDOI
Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor.
TLDR
The structure and function of the α9α10 nAChR are highlighted and studies of α-conotoxins targeting it are reviewed, including their three-dimensional structures, structure optimization strategies, and binding modes at the α 9α10nA chR, as well as their therapeutic potential.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2021-06-01. It has received 22 citations till now. The article focuses on the topics: Nicotinic acetylcholine receptor & Nicotinic agonist.read more
Citations
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Marine natural products.
TL;DR: In this paper , a review of the literature published in 2019 for marine natural products (MNPs) with 736 citations (724 for the period January to December 2021) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Marine natural products.
TL;DR: A review of the literature published in 2020 for marine natural products (MNPs), with 757 citations (747 for the period January to December 2020) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms as discussed by the authors .
Journal ArticleDOI
Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
Nan Zheng,Sean Christensen,Cheryl Dowell,Landa Purushottam,Jack J. Skalicky,J. Michael McIntosh,J. Michael McIntosh,Danny Hung-Chieh Chou +7 more
TL;DR: In this article, the authors used methylene thioacetal as a disulfide surrogate in conotoxin-based peptide drugs for the treatment of neuropathic pain.
Journal ArticleDOI
α9-Containing Nicotinic Receptors in Cancer
TL;DR: The aim of this review is to summarize recent data showing the involvement of these receptors in controlling the downstream signaling cascades involved in the promotion of cancer.
Journal ArticleDOI
Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors.
TL;DR: In this paper, C. geographus α-conotoxins were chemically synthesized as globular and ribbon isomers and their activity investigated at human nAChRs expressed in Xenopus oocytes using the two-electrode voltage clamp recording technique.
References
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
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Gary J. Bennett,Y.-K. Xie +1 more
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A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.
Katjuša Brejc,W.J. van Dijk,Remco V. Klaassen,M. Schuurmans,J. van der Oost,J. van der Oost,August B. Smit,Titia K. Sixma +7 more
TL;DR: The crystal structure of molluscan acetylcholine-binding protein (AChBP), a structural and functional homologue of the amino-terminal ligand-binding domain of an nAChR α-subunit, is presented and is relevant for the development of drugs against Alzheimer’s disease and nicotine addiction.
Journal ArticleDOI
Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution
TL;DR: A comparison of the structure of the alpha subunit with that of AChBP having ligand present, suggests how the localised rearrangement overcomes the distortions and initiates the rotational movements associated with opening of the channel.
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