Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy
Fabio Cofano,Marina Boido,Matteo Monticelli,Francesco Zenga,Alessandro Ducati,Alessandro Vercelli,Diego Garbossa +6 more
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TLDR
The therapeutic role of MSCs is discussed, together with their properties, application, limitations, and future perspectives.Abstract:
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial phase in the pathophysiological process of SCI concerns the well-known secondary injury, which is the uncontrolled and destructive cascade occurring later with aberrant molecular signaling, inflammation, vascular changes, and secondary cellular dysfunctions. The use of mesenchymal stem cells (MSCs) represents one of the most important and promising tested strategies. Their appeal, among the other sources and types of stem cells, increased because of their ease of isolation/preservation and their properties. Nevertheless, encouraging promise from preclinical studies was followed by weak and conflicting results in clinical trials. In this review, the therapeutic role of MSCs is discussed, together with their properties, application, limitations, and future perspectives.read more
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WJSC 6~(th) Anniversary Special Issues(2):Mesenchymal stem cells Mesenchymal stem cells in the treatment of spinal cord injuries:A review
TL;DR: In this paper, the mesenchymal stem cells (MSCs) from various sources with novel and promising strategies are developed to improve function after spinal cord injuries and characteristics and the potential sources of MSCs that can be used in the treatment of SCI.
Human Nervous System
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Journal ArticleDOI
Treatment of spinal cord injury with mesenchymal stem cells
TL;DR: Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation, which are crucial for the restoration of spinal cord function upon SCI.
Journal ArticleDOI
Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies
TL;DR: This review discusses the possible mechanisms of stem cell Therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal Cord injury.
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Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications
Wei-Zhan Zhuang,Yi-Heng Lin,Yi-Heng Lin,Long-Jyun Su,Meng-Shiue Wu,Han-Yin Jeng,Huan-Cheng Chang,Huan-Cheng Chang,Yen Hua Huang,Thai-Yen Ling +9 more
TL;DR: In this article, the authors summarized the current state of mesenchymal stem/stromal cells (MSCs) based cell therapy, focusing on the systemic safety and biodistribution of MSCs.
References
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Patricia A. Zuk,Min Zhu,Hiroshi Mizuno,Jerry I. Huang,Futrell Jw,Adam J. Katz,Prosper Benhaim,H. P. Lorenz,Marc H. Hedrick +8 more
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Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
Massimo Di Nicola,Carmelo Carlo-Stella,Michele Magni,Marco Milanesi,Paolo Longoni,Paola Matteucci,Salvatore Grisanti,Alessandro M. Gianni +7 more
TL;DR: The data demonstrate that autologous or allogeneic BMSCs strongly suppress T-lymphocyte proliferation, this phenomenon that is triggered by both cellular as well as nonspecific mitogenic stimuli has no immunologic restriction, and T-cell inhibition is not due to induction of apoptosis and is likely due to the production of soluble factors.
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Human mesenchymal stem cells modulate B-cell functions
Anna Corcione,Federica Benvenuto,Elisa Ferretti,Debora Giunti,Valentina Cappiello,Francesco Cazzanti,Marco Risso,Francesca Gualandi,Giovanni Luigi Mancardi,Vito Pistoia,Antonio Uccelli +10 more
TL;DR: The results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role.
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G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
Isabelle Petit,Martine Szyper-Kravitz,Arnon Nagler,Meir Lahav,Amnon Peled,Liliana Habler,Tanya Ponomaryov,Russell S. Taichman,Fernando Arenzana-Seisdedos,Nobutaka Fujii,Judith Sandbank,Dov Zipori,Tsvee Lapidot +12 more
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