Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.
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It is suggested that MesP2 controls sclerotomal polarity by regulating the signaling systems mediated by notch-delta and FGF, which are essential for segmentation.Abstract:
We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm. Mesp2 is expressed in the rostral presomitic mesoderm, but down-regulated immediately after the formation of the segmented somites. To determine the function of MesP2 protein (MesP2) in somitogenesis, we generated Mesp2-deficient mice by gene targeting. The homozygous Mesp2 (-/-) mice died shortly after birth and had fused vertebral columns and dorsal root ganglia, with impaired sclerotomal polarity. The earliest defect in the homozygous embryos was a lack of segmented somites. Their disruption of the metameric features, altered expression of Mox-1, Pax-1, and Dll1, and lack of expression of Notch1, Notch2, and FGFR1 suggested that MesP2 controls sclerotomal polarity by regulating the signaling systems mediated by notch-delta and FGF, which are essential for segmentation.read more
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References
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Journal ArticleDOI
Notch1 is required for the coordinate segmentation of somites
TL;DR: It is proposed that Notch1 normally coordinates the process of somitogenesis, and a model of how this might occur is provided, and it is found that som itogenesis is delayed and disorganized in Notch 1 mutant embryos.
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Identification of neurogenin, a Vertebrate Neuronal Determination Gene
TL;DR: A novel, NeuroD-related bHLH protein, NEUROGENIN, whose expression precedes that of NeuroD in both mouse and Xenopus is described, suggesting that it functions as a vertebrate neuronal determination factor.
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fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.
TL;DR: It is suggested that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation.
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A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.
Diane G. Edmondson,Eric N. Olson +1 more
TL;DR: The existence of a family of myogenic regulatory genes that share a conserved motif with c-myc is suggested, which is sufficient to activate the muscle differentiation program and may substitute for MyoD1 in certain developmental situations.
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Murine FGFR-1 is required for early postimplantation growth and axial organization.
TL;DR: It is demonstrated that FGFR-1 is required for proper embryonic cell proliferation and for the correct axial organization of early postimplantation embryos but not for mesoderm formation.