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Open AccessJournal ArticleDOI

Metabolic surgery in China: present and future.

TLDR
In this article, the authors review the current efficacy and safety of metabolic surgery, as well as recent progress in mechanistic studies and surgical procedures in China, and propose a new type of treatment with unique advantages in weight loss and obesity-related metabolic complications.
Abstract
Obesity and its related complications comprise a serious public health problem worldwide, and obesity is increasing in China. Metabolic surgery is a new type of treatment with unique advantages in weight loss and obesity-related metabolic complications. The pathogenesis of obesity is complex and not yet fully understood. Here, we review the current efficacy and safety of metabolic surgery, as well as recent progress in mechanistic studies and surgical procedures in China. The exciting and rapid advances in this field provide new opportunities for patients with obesity and strike a balance between long-term effectiveness and safety.

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References
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Journal ArticleDOI

Health Effects of Overweight and Obesity in 195 Countries over 25 Years.

Ashkan Afshin, +167 more
TL;DR: The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence‐based interventions to address this problem.
Journal ArticleDOI

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes

TL;DR: Five‐year outcome data showed that, among patients with type 2 diabetes and a BMI of 27 to 43, bariatric surgery plus intensive medical therapy was more effective thanintensive medical therapy alone in decreasing, or in some cases resolving, hyperglycemia.
Journal ArticleDOI

Bile acids as regulatory molecules.

TL;DR: Current knowledge of how bile acids regulate hepatic lipid and glucose metabolism through the activation of specific nuclear receptors and cell signaling pathways is summarized.