Metal nanoparticles: understanding the mechanisms behind antibacterial activity.
TLDR
Proposed mechanisms of antibacterial action of different metal NPs include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction.Abstract:
As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.read more
Citations
More filters
Journal ArticleDOI
Metal-based nanoparticles as antimicrobial agents: an overview.
Elena Sánchez-López,Elena Sánchez-López,Daniela Gomes,Gerard Esteruelas,Lorena Bonilla,Ana López-Machado,Ana López-Machado,Ruth Galindo,Amanda Cano,Amanda Cano,Marta Espina,Miren Ettcheto,Miren Ettcheto,Antoni Camins,Antoni Camins,Amélia M. Silva,Alessandra Durazzo,Antonello Santini,Maria Luisa García,Maria Luisa García,Eliana B. Souto,Eliana B. Souto +21 more
TL;DR: Their added-value in the development of alternative, more effective antibiotics against multi-resistant Gram-negative bacteria has been highlighted and their production methods, physicochemical characterization, and pharmacokinetics are reviewed.
Journal ArticleDOI
Green synthesis of silver nanoparticles: biomolecule-nanoparticle organizations targeting antimicrobial activity
TL;DR: The recent advances in green synthesis of silver nanoparticles, their application as antimicrobial agents and mechanism of antimicrobial mode of action are discussed.
Journal ArticleDOI
Nano-Strategies to Fight Multidrug Resistant Bacteria-"A Battle of the Titans".
Pedro V. Baptista,Matthew P. McCusker,Andreia Carvalho,Daniela Alves Ferreira,Niamh M. Mohan,Marta Martins,Alexandra R. Fernandes +6 more
TL;DR: The use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this, so the current research on nanoparticles and other nanomaterials are summarized.
Journal ArticleDOI
Bactericidal and Cytotoxic Properties of Silver Nanoparticles.
TL;DR: A state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings is provided.
Journal ArticleDOI
Green Synthesis of Metallic Nanoparticles and Their Prospective Biotechnological Applications: an Overview
Salem S. Salem,Amr Fouda +1 more
TL;DR: This review will address biological entities that can be used for the green synthesis of NPs and their prospects for biotechnological applications.
References
More filters
Journal ArticleDOI
The green fluorescent protein
TL;DR: In just three years, the green fluorescent protein from the jellyfish Aequorea victoria has vaulted from obscurity to become one of the most widely studied and exploited proteins in biochemistry and cell biology.
Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus.
TL;DR: The existence of elements of silver and sulfur in the electron-dense granules and cytoplasm detected by X-ray microanalysis suggested the antibacterial mechanism of silver: DNA lost its replication ability and the protein became inactivated after Ag(+) treatment.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.