Microarray Evaluation of Dietary Restriction
Eun Soo Han,Morgen Hickey +1 more
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TLDR
It seems that individual genes altered in the expression by DR were constrained within species, and certain functions such as metabolism, energy metabolism, stress and immune response, cell growth, and transcription regulation were shared among species.Abstract:
Dietary restriction (DR) extends the life span and retards many age-related cellular and molecular changes in laboratory rodents. However, neither its underlying mechanism nor the limits of its action are fully understood. In this review, we assessed the effect of DR on gene expression in vertebrate and invertebrate animals using data generated by microarrays. Altered genes in DR mice reported in 15 articles published since 1999 were compared. A comparison of altered genes by DR in mice, rats, pigs, monkeys, yeast, and flies showed no common gene altered by DR among different species. It seems that individual genes altered in the expression by DR were constrained within species. When we compared the functions of altered genes across all species, we found that certain functions such as metabolism, energy metabolism, stress and immune response, cell growth, and transcription regulation were shared among species. Although individual genes seem to be affected by DR differently among species, the overall physiologic influence of DR may be similar.read more
Citations
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Large scale comparison of global gene expression patterns in human and mouse
TL;DR: The results indicate that the global patterns of tissue-specific expression of orthologous genes are conserved in human and mouse.
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Cross species analysis of microarray expression data
TL;DR: This review discusses the computational and technical challenges associated with cross-species analysis of microarray data, the approaches that have been developed to address these challenges, and how successful application of these methods lead to insights that cannot be obtained when analyzing data from a single species.
Journal ArticleDOI
A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms
Michael Plank,Daniel Wuttke,Sipko van Dam,Susan A. Clarke,Susan A. Clarke,João Pedro de Magalhães +5 more
TL;DR: A meta-analysis of microarray CR studies in mammals identified genes and processes robustly altered due to CR and revealed candidate regulators of transcriptional modules in CR, hinting at a transcriptional module involved in sterol metabolism regulated by Srebf1.
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Feed restriction strategy in the growing rabbit. 1. Impact on digestion, rate of passage and microbial activity.
Thierry Gidenne,A. Feugier +1 more
TL;DR: The effects of a quantitative feed restriction on the digestive physiology of the young rabbit remain largely unclear and the digestibility was not significantly affected by the restriction level, although the butyrate proportion tended to be higher in restricted animals.
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Assessment of Diet‐induced Obese Rats as an Obesity Model by Comparative Functional Genomics
Shuyu Li,Hong-Yan Zhang,Charlie C. Hu,Frank Lawrence,Kelly E. Gallagher,Anupama Surapaneni,Shawn T. Estrem,John N. Calley,Gabor Varga,Ernst R. Dow,Yanyun Chen +10 more
TL;DR: A comparative functional genomics approach was applied to evaluate whether diet‐induced obese (DIO) rats serve as an effective obesity model.
References
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Journal ArticleDOI
Gene Expression Profile of Aging and Its Retardation by Caloric Restriction
TL;DR: Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.
Journal ArticleDOI
Gene-expression profile of the ageing brain in mice.
TL;DR: Caloric restriction, which retards the ageing process in mammals, selectively attenuated the age-associated induction of genes encoding inflammatory and stress responses, which resulted in a gene-expression profile indicative of an inflammatory response, oxidative stress and reduced neurotrophic support in both brain regions.
Journal ArticleDOI
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Su Ju Lin,Matt Kaeberlein,Alex A. Andalis,Lori A. Sturtz,Pierre-Antoine Defossez,Pierre-Antoine Defossez,Valeria C. Culotta,Gerald R. Fink,Leonard Guarente +8 more
TL;DR: In this paper, a model of calorie restriction in yeast Saccharomyces cerevisiae was established and it was shown that the shunting of carbon metabolism toward the mitochondrial tricarboxylic acid cycle and the concomitant increase in respiration play a central part in this process.
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Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster
Scott D. Pletcher,Stuart J. Macdonald,Richard Marguerie,Ulrich Certa,Stephen C. Stearns,David Goldstein,Linda Partridge +6 more
TL;DR: In this article, the authors characterized RNA transcript levels for the whole Drosophila genome during normal aging and found that nearly 23% of the genome changed in transcript representation with age.
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Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior
TL;DR: The recent application of modern methods of molecular and cellular biology to the problem of brain aging is revealing a remarkable capacity within brain cells for adaptation to aging and resistance to disease.