Journal ArticleDOI
Microglial cell population dynamics in the injured adult central nervous system.
Rune Ladeby,Martin Wirenfeldt,Daniel Garcia-Ovejero,Christina Fenger,Lasse Dissing-Olesen,Ishar Dalmau,Bente Finsen +6 more
Reads0
Chats0
TLDR
The demonstration of an injury-enhanced recruitment of bone marrow-derived cells into the perforant path-denervated dentate gyrus, raises the possibility of using genetically manipulated cells as vectors for lesion-site-specific gene therapy even in minimally injured areas of the central nervous system.About:
This article is published in Brain Research Reviews.The article was published on 2005-04-01. It has received 332 citations till now. The article focuses on the topics: Neuroinflammation & Neuroglia.read more
Citations
More filters
Journal ArticleDOI
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
TL;DR: This review focuses on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
Journal ArticleDOI
Physiology of Microglia
TL;DR: Current studies indicate that even in the normal brain, microglia have highly motile processes by which they scan their territorial domains, and microglial cells are considered the most susceptible sensors of brain pathology.
Journal ArticleDOI
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.
Bahareh Ajami,Jami Bennett,Charles Krieger,Charles Krieger,Wolfram Tetzlaff,Fabio M.V. Rossi +5 more
TL;DR: No evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease is found, suggesting that maintenance and local expansion ofmicroglia are solely dependent on the self-renewal of CNS resident cells in these models.
Journal ArticleDOI
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
TL;DR: Evidence supports that the unregulated activation of microglia in response to environmental toxins, endogenous proteins, and neuronal death results in the production of toxic factors that propagate neuronal injury.
Journal ArticleDOI
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.
TL;DR: In vivo evidence of a neuroprotective role of proliferating microglia serving as an endogenous pool of neurotrophic molecules such as IGF-1 is reported, which may open new therapeutic avenues in the treatment of stroke and other neurological disorders.
References
More filters
Journal ArticleDOI
The three-dimensional organization of the hippocampal formation: a review of anatomical data.
David G. Amaral,Menno P. Witter +1 more
TL;DR: It is concluded that it is heuristically most reasonable to consider the hippocampal formation as a three-dimensional cortical region with important information processing taking place in both the transverse and long axes.
Journal ArticleDOI
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
TL;DR: Examination of the distribution of microglia in the normal adult mouse brain using immunocytochemical detection of the macrophage specific plasma membrane glycoprotein F4/80 found no evidence of monocyte-like cells in the adult CNS.
Journal ArticleDOI
Microglia-specific localisation of a novel calcium binding protein, Iba1
TL;DR: Results indicated that localisation of Iba1 protein is restricted to microglia both in vitro and in vivo, and that Iba 1 protein plays a role in regulating the function of microglIA, especially in the activated microglial.
Journal ArticleDOI
Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.
W. Wiktor-Jedrzejczak,A. Bartocci,Anthony W. Ferrante,A. Ahmed-Ansari,Kenneth W. Sell,Jeffrey W. Pollard,E R Stanley +6 more
TL;DR: Serum, 11 tissues, and different cell and organ conditioned media from op/op mice were shown to be devoid of biologically active colony-stimulating factor 1 (CSF-1), whereas all of these preparations from littermate control +/+ and +/operative mice contained the growth factor.
Journal ArticleDOI
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
TL;DR: The results suggest that lipid-soluble tetracyclines, doxycycline and minocycline, inhibit inflammation and are neuroprotective against ischemic stroke, even when administered after the insult.