Journal ArticleDOI
Microsomal oxidative damage promoted by acetaminophen metabolism
María Eugenia Letelier,Miguel López-Valladares,Liliana Peredo-Silva,Daniel Rojas-Sepúlveda,Paula Aracena +4 more
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TLDR
Data suggest that ROS generation following incubation of microsomes with acetaminophen and NADPH appears to be mainly caused by a NOX activity, and toxicity ofacetaminophen is discussed.About:
This article is published in Toxicology in Vitro.The article was published on 2011-10-01. It has received 40 citations till now. The article focuses on the topics: Apocynin & NAPQI.read more
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Role of endoplasmic reticulum stress in drug‐induced toxicity
TL;DR: This review summarizes the main data pertaining to drug‐induced ER stress and its potential involvement in different adverse effects and includes data on tunicamycin and thapsigargin since both molecules are commonly used as prototypical toxins to induce ER stress in cellular and animal models.
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Toxic potential of paracetamol to freshwater organisms: A headache to environmental regulators?
TL;DR: The results show that paracetamol toxicity is widely variable among species, even when these species are phylogenetically related, providing evidence of the inadequacy of standardized toxicity testing guidelines for pharmaceutical compounds in wild organisms.
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TRPM2 channels mediate acetaminophen-induced liver damage
TL;DR: It is shown that acetaminophen-induced liver toxicity depends on Transient Receptor Potential Melanostatine 2 (TRPM2) cation channels in hepatocytes, which are activated in response to oxidative stress and are responsible for Ca2+ overload, and that TRPM2 may present a potential therapeutic target for treatment of oxidative-stress related liver diseases.
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Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage
A. S. Ramos,Alberto Teodorico Correia,Alberto Teodorico Correia,Sara C. Antunes,Sara C. Antunes,Fernando Gonçalves,Bruno Nunes +6 more
TL;DR: Assessment of the toxic effects of acetaminophen in Oncorhynchus mykiss following acute and chronic exposures in realistic levels indicates that a significant response of oxidative stress was established, along with the increase of APAP concentrations.
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Dissecting the molecular pathophysiology of drug-induced liver injury
Hui Ye,Leonard J Nelson,Manuel Gómez del Moral,Eduardo Martínez-Naves,Francisco Javier Cubero +4 more
TL;DR: The pathophysiological mechanisms underlying DILI are discussed and common forms of hepatocyte death and their association with the activation of specific signaling pathways are examined.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Tissue sulfhydryl groups
TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
Journal ArticleDOI
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Jozef Sedlak,Raymond H. Lindsay +1 more
TL;DR: A simple spectrophotometric method for the routine concomitant determination of sulfhydryl groups in PB- SH, NP-SH, and T-SH fractions in various tissues is reported.
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Nox proteins in signal transduction
TL;DR: This review will discuss recent literature on Nox protein tissue distribution, subcellular localization, activation, and the resulting signal transduction mechanisms.
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N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.
TL;DR: N-acetylcysteine is a safe, well-tolerated antidote for cysteine/GSH deficiency and has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD.
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Intracellular Signaling Mechanisms of Acetaminophen-Induced Liver Cell Death
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