Miller Fisher syndrome and polyneuritis cranialis in COVID-19.
Consuelo Gutiérrez-Ortiz,Antonio Méndez-Guerrero,Sara Rodrigo-Rey,Eduardo San Pedro-Murillo,Laura Bermejo-Guerrero,Ricardo Gordo-Mañas,Fernando de Aragón-Gómez,Julián Benito-León +7 more
TLDR
2 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who presented acutely with Miller Fisher syndrome and polyneuritis cranialis make a complete neurologic recovery, except for residual anosmia and ageusia in the first case.Abstract:
Objective: To report two patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) who acutely presented with Miller Fisher syndrome and polyneuritis cranialis, respectively. Methods: Patient data were obtained from medical records from the University Hospital “Principe de Asturias”, Alcala de Henares, Madrid, Spain and from the University Hospital “12 de Octubre”, Madrid, Spain. Results: The first patient was a 50-year-old man who presented with anosmia, ageusia, right internuclear ophthalmoparesis, right fascicular oculomotor palsy, ataxia, areflexia, albuminocytologic dissociation and positive testing for GD1b-IgG antibodies. Five days before, he had developed a cough, malaise, headache, low back pain, and a fever. The second patient was a 39-year-old man who presented with ageusia, bilateral abducens palsy, areflexia and albuminocytologic dissociation. Three days before, he had developed diarrhea, a low-grade fever, and a poor general condition. The oropharyngeal swab test for coronavirus disease 2019 (COVID-19) by qualitative real-time reverse-transcriptase–polymerase-chain-reaction assay was positive in both patients and negative in the cerebrospinal fluid. The first patient was treated with intravenous immunoglobulin and the second, with acetaminophen. Two weeks later, both patients made a complete neurological recovery, except for residual anosmia and ageusia in the first case. Conclusions: Our two cases highlight the rare occurrence of Miller Fisher syndrome and polyneuritis cranialis during the COVID-2 pandemic. Neurological manifestations may occur because of an aberrant immune response to COVID-19. The full clinical spectrum of neurological symptoms in patients with COVID-19 remains to be characterized.read more
Citations
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Neurological Associations of COVID-19
Mark Ellul,Laura A Benjamin,Bhagteshwar Singh,Suzannah Lant,Benedict D Michael,Benedict D Michael,Ava Easton,Rachel Kneen,Sylviane Defres,James Sejvar,Tom Solomon,Tom Solomon,Tom Solomon +12 more
TL;DR: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is of a scale not seen since the 1918 influenza pandemic and the proportion of infections leading to neurological disease will probably remain small.
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Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.
Jakob Matschke,Marc Lütgehetmann,Christian Hagel,Jan Sperhake,Ann Sophie Schröder,Carolin Edler,Herbert Mushumba,Antonia Fitzek,Lena Allweiss,Maura Dandri,Matthias Dottermusch,Axel Heinemann,Susanne Pfefferle,Marius Schwabenland,Daniel Sumner Magruder,Stefan Bonn,Stefan Bonn,Marco Prinz,Christian Gerloff,Klaus Püschel,Susanne Krasemann,Martin Aepfelbacher,Markus Glatzel +22 more
TL;DR: In general, neuropathological changes in patients with COVID-19 seem to be mild, with pronounced neuroinflammatory changes in the brainstem being the most common finding, and there was no evidence for CNS damage directly caused by SARS-CoV-2.
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Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review.
Adeel S. Zubair,Lindsay S. McAlpine,Tova M. Gardin,Shelli F. Farhadian,Deena E. Kuruvilla,Serena Spudich +5 more
TL;DR: The most common neurologic complaints in COVID-19 are anosmia, ageusia, and headache, but other diseases, such as stroke, impairment of consciousness, seizure, and encephalopathy, have also been reported.
Journal ArticleDOI
Neurological Associations of COVID-19
Mark Ellul,Laura A Benjamin,Laura A Benjamin,Bhagteshwar Singh,Suzannah Lant,Benedict D Michael,Ava Easton,Rachel Kneen,Sylviane Defres,James Sejvar,Tom Solomon +10 more
TL;DR: The COVID-19 pandemic, caused by SARS-CoV-2, is of a scale not seen since the 1918 influenza pandemic and so much of the population infected, the overall number of neurological patients, and their associated health, social and economic costs, may be large.
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Effects of COVID-19 on the Nervous System.
TL;DR: A critical appraisal of the potential for neurotropism and mechanisms of neuropathogenesis of SARS-CoV-2, as they relate to the acute and chronic neurological consequences of the infection is provided.
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