Journal ArticleDOI
miR-99a and -99b inhibit cervical cancer cell proliferation and invasion by targeting mTOR signaling pathway
TLDR
Results suggested that miR-99a/b directly and negatively regulated mTOR expression in cervical cancer cells, and enforced the importance of miR/b and their targets in the malignant phenotypes of cervical carcinogenesis.Abstract:
MicroRNAs were demonstrated to play an important role in the regulation of gene expression. Here, we showed that miR-99a and -99b (miR-99a/b) were down-regulated in human cervical cancer patient tissues and were negatively related with lymphatic metastasis. In addition, overexpression of miR-99a/b inhibited cell growth and invasion, whereas suppression of miR-99a/b yielded the reverse phenotype. Dual luciferase report assay revealed that mTOR was identified as a novel target gene of both miR-99a and -99b. Altogether, these results suggested that miR-99a/b directly and negatively regulated mTOR expression in cervical cancer cells, and enforced the importance of miR-99a/b and their targets in the malignant phenotypes of cervical carcinogenesis.read more
Citations
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Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells.
TL;DR: It is shown that human adipose MSC (hAMSC)-derived conditioned medium (CM) exhibited inhibitory effects on A2780 human ovarian cancer cells by blocking the cell cycle, and activating mitochondria-mediated apoptosis signalling, and sequencing of exosomal RNAs revealed a rich population of microRNAs, which exhibit anti-cancer activities by targeting different molecules associated with cancer survival.
Journal ArticleDOI
microRNAs: New prognostic, diagnostic, and therapeutic biomarkers in cervical cancer.
Javid Sadri Nahand,Sima Taghizadeh-Boroujeni,Mohammad Karimzadeh,Sarina Borran,Mohammad Hossein Pourhanifeh,Mohsen Moghoofei,Farah Bokharaei-Salim,Sajad Karampoor,Amir Jafari,Zatollah Asemi,Alireza Tbibzadeh,Afshin Namdar,Hamed Mirzaei +12 more
TL;DR: Various miRNAs are summarized as an employable platform for prognostic, diagnostic, and therapeutic biomarkers in the treatment of cervical cancer.
Journal ArticleDOI
The Role of microRNAs, Long Non-coding RNAs, and Circular RNAs in Cervical Cancer.
Maria Lina Tornesello,Raffaella Faraonio,Luigi Buonaguro,Clorinda Annunziata,Noemy Starita,Andrea Cerasuolo,Francesca Pezzuto,Anna Lucia Tornesello,Franco M. Buonaguro +8 more
TL;DR: Current literature on the complex interplay between miRNAs, lnc RNAs, and circRNAs and their role in cervical neoplasia is summarized.
Journal ArticleDOI
Regulation of IGF -1 signaling by microRNAs
Hwa Jin Jung,Yousin Suh +1 more
TL;DR: The components of the IGF-1 signaling pathway that are known targets of miRNA regulation are reviewed, and recent studies that suggest therapeutic potential of these miRNAs against various diseases are highlighted.
Journal ArticleDOI
Emerging Role of MicroRNAs in mTOR Signaling
TL;DR: An overview of current knowledge regarding the reciprocal relationship between miRNAs and mTOR pathway: regulation of mTOR signaling by miRNAAs and control of miRNA biogenesis by mTOR is provided.
References
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Journal ArticleDOI
The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
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mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
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Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis.
TL;DR: It is concluded that miRNA-mediated regulation has a complexity of cellular outcomes and that miRNAs can be mediators of regulation of cell growth and apoptosis pathways.
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The coordinate regulation of the p53 and mTOR pathways in cells.
TL;DR: The results presented here demonstrate that activation of p53 inhibits mTOR activity and regulates its downstream targets, including autophagy, a tumor suppression process, and that p53 and mTOR signaling machineries can cross-talk and coordinately regulate cell growth, proliferation, and death.