Mitochondria containing extracellular vesicles from autologous induced pluripotent stem cell derived cardiomyocytes restore bioenergetics in ischemic myocardium
Gentaro Ikeda,Michelle R. Santoso,Yuko Tada,Evgeniya Vaskova,Connor O'Brien,Ji Hye Jung,Phillip C. Yang +6 more
TLDR
Extracellular vesicle (EV)-mediated transfer of autologous mitochondria and their related energy source may enhance cardiac function following myocardial injury through restoration of myocardious function.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2020-03-24 and is currently open access. It has received 2 citations till now. The article focuses on the topics: Extracellular vesicle & Energy source.read more
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Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.
Connor O'Brien,Mehmet Ozgun Ozen,Gentaro Ikeda,Evgeniya Vaskova,Ji Hye Jung,Nathan Bayardo,Michelle R. Santoso,Liye Shi,Christine Wahlquist,Zewen Jiang,Yunshin Jung,Yitian Zeng,Elizabeth S. Egan,Robert Sinclair,Adrian P. Gee,Ronald M. Witteles,Mark Mercola,Katrin J. Svensson,Utkan Demirci,Phillip C. Yang +19 more
TL;DR: An in vitro clinical trial evaluating the efficacy and putative mechanisms of SENECA trial–specific MSCs in treating doxorubicin (DOX) injury suggested a mechanism by which MSC's may improve cardiovascular performance in AIC independent of regeneration, which could inform future trial design evaluating the therapeutic potential of M SCs.