Journal ArticleDOI
Mitochondrial function, blastocyst development and live foals born after ICSI of immature vitrified/warmed equine oocytes matured with or without melatonin.
G. Clérico,G. Taminelli,J. C. Veronesi,J. Polola,N. Pagura,Carlos R. F. Pinto,M. Sansinena,M. Sansinena,M. Sansinena +8 more
TLDR
It is shown for the first time that in the horse, as in other species, intracellular reactive oxygen species are increased by the process of vitrification and melatonin was useful in reducing mitochondrial-related ROS and improving ICSI embryo development, although the lower pregnancy rate in presence of melatonin should be further analyzed in future studies.About:
This article is published in Theriogenology.The article was published on 2021-01-15. It has received 15 citations till now. The article focuses on the topics: Melatonin & Oocyte.read more
Citations
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Journal ArticleDOI
Oocyte Cryopreservation in Domestic Animals and Humans: Principles, Techniques and Updated Outcomes.
TL;DR: Oocyte cryopreservation plays important roles in basic research and the application of models for genetic preservation and in clinical situations as mentioned in this paper, however, oocytes have remained the most difficult cell type to freeze, as the oocytes per se are large with limited surface area to cytoplasm ratio.
Journal ArticleDOI
Past, present and future of ICSI in livestock species.
O. Briski,DF Salamone +1 more
TL;DR: In this article , an overview and projection of the methodologies and applications that are envisioned for ICSI utilization in these species in the future is presented. But, there are some biological limitations that need to be overcome if this procedure is going to be efficacious for making genetic improvements in livestock.
Journal ArticleDOI
Resveratrol enhanced mitochondrial recovery from cryopreservation‐induced damages in oocytes and embryos
TL;DR: Resveratrol, 3,5,4′‐trihydroxystilbene, is a polyphenolic antioxidant that has versatile target proteins, among which sirtuin‐1 (SIRT1) is a key regulator of in mitochondrial biogenesis and degradation.
Journal ArticleDOI
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway
Shichao Guo,Jinyu Yang,Jianpeng Qin,Izhar Hyder Qazi,Bo Pan,Shengqin Zang,Tianyi Lv,Shoulong Deng,Yi Fang,Guang-Bin Zhou +9 more
TL;DR: In this article, the authors explored whether melatonin could reduce oxidative stress during in vitro maturation of vitrified-warmed mouse germinal vesicle (GV) oocytes through the Nrf2 signaling pathway or its receptors.
Journal ArticleDOI
Melatonin Promotes in vitro Development of Vitrified-Warmed Mouse GV Oocytes, Potentially by Modulating Phosphorylation of Drp1.
Jianpeng Qin,Shichao Guo,Jinyu Yang,Izhar Hyder Qazi,Bo Pan,Tianyi Lv,Shengqin Zang,Yi Fang,Guang-Bin Zhou +8 more
TL;DR: In this article, the authors investigated whether melatonin can improve the mitochondrial function during in vitro maturation of vitrified-warmed mouse germinal vesicle (GV) oocytes by modulating phosphorylation of dynamin related protein 1 (Drp1).
References
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Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
Journal ArticleDOI
Mitochondrial damage induced by conditions of oxidative stress
TL;DR: Up to 2% of the oxygen consumed by the mitochondrial respiratory chain undergoes one electron reduction, typically by the semiquinone form of coenzyme Q, to generate the superoxide radical, and subsequently other reactive oxygen species such as hydrogen peroxide and the hydroxyl radical.
Journal ArticleDOI
Mitochondrial dynamics and inheritance during cell division, development and disease.
Prashant Mishra,David C. Chan +1 more
TL;DR: Mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion–fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes.
Journal ArticleDOI
Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
Hiroshi Tamura,Akihisa Takasaki,Ichiro Miwa,Ken Taniguchi,Ryo Maekawa,Hiromi Asada,Toshiaki Taketani,Aki Matsuoka,Yoshiaki Yamagata,Katsunori Shimamura,Hitoshi Morioka,Hitoshi Ishikawa,Russel J. Reiter,Norihiro Sugino +13 more
TL;DR: It is concluded that oxidative stress causes toxic effects on oocyte maturation and melatonin protects oocytes from oxidative stress and is likely to improve oocyte quality and fertilization rates.
Journal ArticleDOI
Melatonin mitigates mitochondrial malfunction
TL;DR: Melatonin effects reflect the ability of melatonin to reduce the harmful reduction in the mitochondrial membrane potential that may trigger mitochondrial transition pore (MTP) opening and the apoptotic cascade, and opens a new perspective in the understanding of the regulation of apoptotic cell death by the indoleamine.