Mitochondrial dynamics and inheritance during cell division, development and disease.
Prashant Mishra,David C. Chan +1 more
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TLDR
Mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion–fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes.Abstract:
During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features - including their own genome and a maternal mode of germline transmission - that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion-fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.read more
Citations
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Mitochondrial Dynamics and Metabolic Regulation.
Timothy Wai,Thomas Langer +1 more
TL;DR: The ways in which metabolic alterations convey changes in mitochondrial morphology and how disruption of mitochondrial morphology impacts cellular and organismal metabolism are reviewed.
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Mitochondrial ROS Signaling in Organismal Homeostasis
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Metabolic regulation of mitochondrial dynamics
Prashant Mishra,David C. Chan +1 more
TL;DR: This work reviews the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.
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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Erin Quan Toyama,Sébastien Herzig,Julien Courchet,Tommy L. Lewis,Oliver C. Losón,Kristina Hellberg,Nathan P. Young,Hsiuchen Chen,Franck Polleux,David C. Chan,Reuben J. Shaw +10 more
TL;DR: The energy-sensing adenosine monophosphate (AMP)–activated protein kinase (AMPK) is genetically required for cells to undergo rapid mitochondrial fragmentation after treatment with ETC inhibitors and direct pharmacological activation of AMPK was sufficient to rapidly promote mitochondrial fragmentation even in the absence of mitochondrial stress.
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Mitochondrial dynamics and mitochondrial quality control.
TL;DR: This review discusses the most recent progress on the molecular mechanisms and roles of mitochondrial fission/fusion and mitochondrial motility in mitophagy, and discusses multiple pathways leading to the quality control of mitochondria in addition to the traditionalMitophagy pathway under different conditions.
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