Journal ArticleDOI
Modeling and simulation of spatial-temporal calcium distribution in T lymphocyte cell by using a reaction-diffusion equation
Parvaiz Ahmad Naik,Jian Zu +1 more
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TLDR
A quantitative spatio-temporal Ca2+ dynamic model is developed which includes, theCa2+ releasing channels ER leak and voltage-gated Ca2- channel, buffering and re-uptaking mechanism in the T lymphocytes, and the coordinated combination of the incorporated parameters plays a significant role in Ca2+.Abstract:
T lymphocytes are white blood cells that play a central role in cell-mediated immunity. Ca2+ has its major signaling function when it is elevated in the cytosolic compartment. The free cytosolic Ca...read more
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Molecular docking suggests repurposing of brincidofovir as a potential drug targeting SARS-CoV-2 ACE2 receptor and main protease
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Effect of disturbances in neuronal calcium and IP3 dynamics on β-amyloid production and degradation
Anand Pawar,Kamal Raj Pardasani +1 more
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Study of disorders in regulatory spatiotemporal neurodynamics of calcium and nitric oxide
Anand Pawar,Kamal Raj Pardasani +1 more
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On a reaction–diffusion model for calcium dynamics in neurons with Mittag–Leffler memory
Hardik Joshi,Brajesh Kumar Jha +1 more
TL;DR: In this paper, the Atangana-Baleanu-Caputo (ABC) derivative is used to solve complex dynamical problems due to its nonlocal and non-singular Mittag-Leffler kernels.
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Interactions of selected cardiovascular active natural compounds with CXCR4 and CXCR7 receptors: a molecular docking, molecular dynamics, and pharmacokinetic/toxicity prediction study
TL;DR: In this paper , the authors investigate molecular docking interactions of four popular cardiovascular-active natural compounds; curcumin, resveratrol, quercetin, and eucalyptol; with CXCL12 and its two receptors (CXCR4 and CXCR7) and predict their drug-like properties.
References
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Journal ArticleDOI
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate
TL;DR: For a transient point source of messenger in cells smaller than 20 microns, IP3 is a global messenger, whereas Ca2+ acts in restricted domains.
Journal ArticleDOI
Calcium Signaling Mechanisms in T Lymphocytes
TL;DR: The complexity of Ca(2+) signals contains a wealth of information that may help to instruct lymphocytes to choose between alternate fates in response to antigenic stimulation and increase the efficiency and specificity of gene activation events.
Journal ArticleDOI
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus.
TL;DR: It is reported that human Hassall's corpuscles express thymic stromal lymphopoietin (TSLP), indicating a critical role in dendritic-cell-mediated secondary positive selection of medium-to-high affinity self-reactive T cells, leading to the generation of CD4+CD25+ regulatory T cells within the thymus.
Journal ArticleDOI
Calcium-binding proteins: selective markers of nerve cells.
TL;DR: The discovery that the symptoms in Parkinson's disease are the consequence of a decrease in the concentration of the neurotransmitter dopamine in the basal ganglia, and that an improvement can be achieved by a dopamine precursor that passes through the blood-brain barrier, has helped to shape the opinion that many neurological and psychiatric diseases can be explained as defects in neurotransmitter systems.
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