Journal ArticleDOI
Moderate hypothermia in neonatal encephalopathy: efficacy outcomes.
Dorothea J. Eicher,Carol L. Wagner,Lakshmi P. Katikaneni,Thomas C. Hulsey,W. Thomas Bass,David A. Kaufman,Michael J. Horgan,Sheila Languani,Jatinder Bhatia,Lawrence M. Givelichian,Koravangatta Sankaran,Jerome Y. Yager +11 more
TLDR
Although these results need to be validated in a large clinical trial, this pilot trial provides important data for clinical trial design of hypothermia treatment in neonatal hypoxic-ischemic injury.About:
This article is published in Pediatric Neurology.The article was published on 2005-01-01. It has received 548 citations till now. The article focuses on the topics: Neonatal encephalopathy & Hypothermia.read more
Citations
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Journal ArticleDOI
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.
Seetha Shankaran,Abbot R. Laptook,Richard A. Ehrenkranz,Jon E. Tyson,Scott A. McDonald,Edward F. Donovan,Avroy A. Fanaroff,W. Kenneth Poole,Linda L. Wright,Rosemary D. Higgins,Neil N. Finer,Waldemar A. Carlo,Shahnaz Duara,William Oh,C. Michael Cotten,David K. Stevenson,Barbara J. Stoll,James A. Lemons,Ronnie Guillet,Alan H. Jobe +19 more
TL;DR: Whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic–ischemic encephalopathy and there was no increase in major disability among survivors.
Journal ArticleDOI
Cooling for newborns with hypoxic ischaemic encephalopathy.
TL;DR: Although two small randomised controlled trials demonstrated neither evidence of benefit or harm, current evidence is inadequate to assess either safety or efficacy of therapeutic hypothermia in newborn infants with hypoxic ischaemic encephalopathy.
Journal ArticleDOI
Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy
Denis Azzopardi,Brenda Strohm,A D Edwards,Leigh Dyet,Henry L. Halliday,Edmund Juszczak,Olga Kapellou,Malcolm I. Levene,Malcolm I. Levene,Neil Marlow,Porter E,Marianne Thoresen,Andrew Whitelaw,Peter Brocklehurst +13 more
TL;DR: Induction of moderate hypothermia for 72 hours in infants who had perinatal asphyxia did not significantly reduce the combined rate of death or severe disability but resulted in improved neurologic outcomes in survivors.
Journal ArticleDOI
Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication ☆ ☆☆ ★: A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke
Jerry P. Nolan,Robert W. Neumar,Christophe Adrie,Mayuki Aibiki,Robert A. Berg,Bernd W. Böttiger,Clifton W. Callaway,Robert S B Clark,Romergryko G. Geocadin,Edward C. Jauch,Karl B. Kern,Ivan Laurent,W. T. Longstreth,Raina M. Merchant,Peter T. Morley,Laurie J. Morrison,Vinay M. Nadkarni,Mary Ann Peberdy,Emanuel P. Rivers,Antonio Rodriguez-Nunez,Frank W. Sellke,Christian Spaulding,Kjetil Sunde,Terry L. Vanden Hoek +23 more
TL;DR: A growing body of knowledge suggests that the individual components of the post-cardiac arrest syndrome are potentially treatable.
Journal ArticleDOI
Post–Cardiac Arrest Syndrome
Robert W. Neumar,Jerry P. Nolan,Christophe Adrie,Mayuki Aibiki,Robert A. Berg,Bernd W. Böttiger,Clifton W. Callaway,Robert S B Clark,Romergryko G. Geocadin,Edward C. Jauch,Karl B. Kern,Ivan Laurent,W. T. Longstreth,Raina M. Merchant,Peter T. Morley,Laurie J. Morrison,Vinay M. Nadkarni,Mary Ann Peberdy,Emanuel P. Rivers,Antonio Rodriguez-Nunez,Frank W. Sellke,Christian Spaulding,Kjetil Sunde,Terry L. Vanden Hoek +23 more
TL;DR: This scientific statement outlines current understanding and identifies knowledge gaps in the pathophysiology, treatment, and prognosis of patients who regain spontaneous circulation after cardiac arrest to provide a resource for optimization of post–cardiac arrest care.
References
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Journal ArticleDOI
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
TL;DR: Selective head cooling, maintained throughout the secondary phase of injury, is noninvasive and safe and shows potential for improving neonatal outcome after perinatal asphyxia.
Journal ArticleDOI
Hypothermia-induced reversible platelet dysfunction.
TL;DR: Data suggest that when a hypothermic patient bleeds without surgical cause, skin and wound temperature should be restored to normal before the administration of blood products that are not only expensive but may also transmit disease.
Journal ArticleDOI
Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome.
Yong Y. Han,Joseph A. Carcillo,Michelle A. Dragotta,Debra M. Bills,Watson Rs,Westerman Me,Richard A. Orr +6 more
TL;DR: Early recognition and aggressive resuscitation of pediatric-neonatal septic shock by community physicians can save lives and educational programs that promote ACCM-PALS recommended rapid, stepwise escalations in fluid as well as inotropic therapies may have value in improving outcomes.
Journal ArticleDOI
Selective head cooling in newborn infants after perinatal asphyxia : A safety study
TL;DR: Mild selective head cooling combined with mild systemic hypothermia in term newborn infants after perinatal asphyxia is a safe and convenient method of quickly reducing cerebral temperature with an increased gradient between the surface of the scalp and core temperature.
Journal ArticleDOI
Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil.
Frederick Colbourne,Dale Corbett +1 more
TL;DR: Increasing the duration of post-ischemic hypothermia from 12 to 24 h produced much greater neuroprotection against severe ischemia, which may be a valuable intervention in stroke patients.
Related Papers (5)
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.
Seetha Shankaran,Abbot R. Laptook,Richard A. Ehrenkranz,Jon E. Tyson,Scott A. McDonald,Edward F. Donovan,Avroy A. Fanaroff,W. Kenneth Poole,Linda L. Wright,Rosemary D. Higgins,Neil N. Finer,Waldemar A. Carlo,Shahnaz Duara,William Oh,C. Michael Cotten,David K. Stevenson,Barbara J. Stoll,James A. Lemons,Ronnie Guillet,Alan H. Jobe +19 more