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Modified hyaluronic acid based materials for biomedical applications

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TLDR
Various transformations in HA through covalent and non-covalent interactions and resulting applications in biomedical fields from the recent literature are described.
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This article is published in International Journal of Biological Macromolecules.The article was published on 2019-01-01. It has received 161 citations till now. The article focuses on the topics: Drug delivery & Targeted drug delivery.

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Citations
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Bio-inspired Surface Imobilization of Hyaluronic Acid on Mondisperse Magnetic Nano-crystals for Targeted Cancer Imaging

TL;DR: The fabrication of stable, bioactive magnetic nanocolloids has proven to be nontrivial as discussed by the authors, and it is of utmost importance to prepare highly stable magnetic nanocrystals in aqueous solutions to maximize in vivo half-life and tissue-specificity.
Journal ArticleDOI

Polymeric Tissue Adhesives.

TL;DR: In this paper, the authors discuss a set of rational guidelines for design of adhesives, recent progress in the field along with examples of commercially available and those under development, tissue-specific considerations, and finally potential functions for future adhesive formulations.
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Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies.

TL;DR: The mechanistic behavior of HA pertaining to its biological synthesis and degradation and the administration of some noteworthy and recent HA based formulations through different routes for application in various physiological conditions are discussed.
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Polysaccharide Based Scaffolds for Soft Tissue Engineering Applications.

TL;DR: The developmental and biological aspects of scaffolds prepared from four polysaccharides, viz. alginic acid (ALG), chitosan (CHI), hyaluronic acid (HA), and dextran (DEX), are discussed and clinical studies on these scaffolds are also discussed.
References
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Journal ArticleDOI

Hydrogels for biomedical applications.

TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
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Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.

TL;DR: A cell labeling approach using short HIV-Tat peptides to derivatize superparamagnetic nanoparticles is developed, which efficiently internalized into hematopoietic and neural progenitor cells in quantities up to 10–30 pg of super paramagnetic iron per cell.
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Polysaccharides-based nanoparticles as drug delivery systems

TL;DR: In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crossl linking, polyelectrolyte complex, and the self-assembly of hydrophobically modified poly Saccharides.
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Hyaluronan fragments: an information-rich system.

TL;DR: The vast range of activities of hyaluronan polymers is reviewed here, in order to determine if patterns can be detected that would provide insight into their production and regulation.
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