Journal ArticleDOI
Modifying role of Phyllanthus emblica and ascorbic acid against nickel clastogenicity in mice.
TLDR
Aqueous extract of edible dried fruits of Phyllanthus emblica was fed to Mus musculus for seven consecutive days prior to treatment with different doses of nickel chloride, finding the greater efficacy of the fruit extract could be due to the interaction of its various natural components rather than to any single constituent.About:
This article is published in Cancer Letters.The article was published on 1991-07-26. It has received 59 citations till now. The article focuses on the topics: Dried fruit & Ascorbic acid.read more
Citations
More filters
Journal ArticleDOI
Review on some plants of Indian traditional medicine with antioxidant activity.
Paolo Scartezzini,Ester Speroni +1 more
TL;DR: Seven plants contain antioxidant principles, that can explain and justify their use in traditional medicine in the past as well as the present, and are viewed for their historical, etymological, morphological, phytochemical and pharmacological aspects.
Journal Article
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6^ collaborative study by CSGMT/JEMS MMS. Collaborative study of the Micronucleus Group Test
TL;DR: Structural-activity relationship analysis suggested that the micronucleus assay is more sensitive to the genetic toxicity of some classes of chemicals than to those carcinogens with stronger evidence human carcinogenicity.
Journal ArticleDOI
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group.
Takeshi Morita,Norihide Asano,Takumi Awogi,Yu F. Sasaki,Sei-ichi Sato,Hiroyasu Shimada,Sizuyo Sutou,Takayoshi Suzuki,Akihiro Wakata,Toshio Sofuni,Makoto Hayashi +10 more
TL;DR: In the 6th MMS/CSGMT collaborative study as mentioned in this paper, IARC groups 1 (human carcinogen), 2A (probable human carcinogen) and 2B (possible human carcinogens) were selected from 100 commercially available chemicals and chemical groups on which there was little or no micronucleus assay data.
Journal ArticleDOI
A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.
TL;DR: There is no convincing evidence that any genotoxic rodent carcinogens or in vivo genotoxins would remain undetected in an in vitro test battery consisting of Ames+MNvit.
References
More filters
Journal ArticleDOI
Plant Antimutagenic Agents, 1. General Bioassay and Isolation Procedures
TL;DR: Methods for isolation and characterization of pure compounds are presented and of particular interest is the utilization of large scale preparative hplc for rapid purification of inhibitory chromatographic fractions that were still highly impure.
Journal ArticleDOI
Antimutagenicity of some citrus fruits in Salmonella typhimurium.
Saroj Bala,I.S. Grover +1 more
TL;DR: The antimutagenic effect of 10 citrus fruit juices was observed against the mutagenicity of N-nitro-o-phenylenediamine (NPD) in TA97a and sodium azide in TA100 tester strains of Salmonella typhimurium using the Ames test, tempting us to believe that in addition to ascorbic acid and citric acid, the presence of other factor(s) possessing antimUTagenic properties cannot be ruled out.
Journal ArticleDOI
Inhibitory effects of dietary vegetables on the in vivo clastogenicity of cyclophosphamide
Book ChapterDOI
Origin and Significance of Chromosomal Alterations
TL;DR: No detectable increase in the frequency of spontaneous point mutations in human populations exposed to ionizing radiations or chemical mutagens has been demonstrated so far, and this point to the importance of understanding the mechanism involved in the origin of chromosomal alterations and their significance.
Journal Article
Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentration and pH.
TL;DR: Promotion of carcinogenesis by L-ascorbic acid and K2CO3 was associated with changes in urinary parameters: elevation of pH, increased K+ concentration, and increase in total ascorbic acid.
Related Papers (5)
Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator.
K Suresh,Damodaran Vasudevan +1 more