Molecular determinants on extracellular loop domains that dictate interaction between β-arrestin and human APJ receptor.
TLDR
The influence of extracellular loop (ECL) domains in the mechanism of β‐arrestin‐mediated signalling from human APJR: Apelin system is demonstrated to play a prominent role in modulating receptor interactions with the β‐Arrestin signalling cascade.About:
This article is published in FEBS Letters.The article was published on 2019-03-01 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Apelin & Arrestin.read more
Citations
More filters
Journal ArticleDOI
Apelin ameliorated acute heart failure via inhibiting endoplasmic reticulum stress in rabbits
Yanqing Li,Haohan Lu,Wenyuan Xu,Yuxuan Shang,Cece Zhao,Yipu Wang,Rui Yang,Sheng Jin,Yuming Wu,Xiaoning Wang,Xu Teng +10 more
TL;DR: Apelin treatment dramatically ameliorated cardiac impairment caused by AHF, which might be mediated by APJ/Akt/ERS signaling pathway, and shed new light on AHF therapy.
Journal ArticleDOI
Critical APJ receptor residues in extracellular domains that influence effector selectivity.
TL;DR: In this paper, the role of extracellular loop (ECL) domain residues of APJ receptor in ligand binding and receptor activation has not been established yet based on multiple sequence alignment of the APJ-APJR receptor from various organisms, identified conserved residues in the extacellular domains Alanine substitutions of specific residues were characterized to evaluate their ligandbinding efficiency and Gq -, Gi -, and β-arrestin-mediated signaling.
Journal ArticleDOI
Comparative Study of Elabela and Apelin on Apelin Receptor Activation Through β-Arrestin Recruitment
TL;DR: In this paper , the effect of ELA and apelin on the interaction between APJ and ARRBs in live cells was investigated by the NanoBiT® system, where two split components of NanoLuc luciferase, large bit (LgBit) and small bit (SmBit), complement each other to form an enzymatically active entity.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform
TL;DR: A simplified scoring system is proposed that performs well for reducing CPU time and increasing the accuracy of alignments even for sequences having large insertions or extensions as well as distantly related sequences of similar length.
Journal ArticleDOI
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Kazuhiko Tatemoto,Masaki Hosoya,Yugo Habata,Ryo Fujii,Tadao Kakegawa,Min-Xu Zou,Yuji Kawamata,Shoji Fukusumi,Shuji Hinuma,Chieko Kitada,Tsutomu Kurokawa,Haruo Onda,Masahiko Fujino +12 more
TL;DR: Synthetic peptides derived from the C-terminal amino acid sequence of bovine preproapelin were capable of specifically promoting the acidification rate in the cells expressing the APJ receptor in a range from 10(-7) to 10(-10) M, indicating that apelin is an endogenous ligand for theAPJ receptor.
Related Papers (5)
Receptor activity-independent recruitment of βarrestin2 reveals specific signalling modes
Sonia Terrillon,Michel Bouvier +1 more