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Movement disorders: Indian scenario: a clinico-genetic review.
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TLDR
Common problems of MDs in India with regard to epidemiology, clinical features and genetics are highlighted.Abstract:
Movement disorder (MD) is an important branch of neurology and has great potentiality in management because of improved diagnosis and therapeutic strategies. Over the last three decades, emphasis has been laid on the evaluation of various MDs in India by a limited number of interested neurologists and basic scientists. In this review, we want to highlight common problems of MDs in India with regard to epidemiology, clinical features and genetics.read more
Citations
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Admixing of MPTP-Resistant and Susceptible Mice Strains Augments Nigrostriatal Neuronal Correlates to Resist MPTP-Induced Neurodegeneration
TL;DR: The core neuroanatomical features of resilience against PD and evidence for ethnicity-based differential prevalence are presented and similar neural correlates of resilience are envisaged in the Anglo-Indian population.
Journal ArticleDOI
Understanding the role of genetic variability in LRRK2 in Indian population
Asha Kishore,Ashwin Ashok Kumar Sreelatha,Marc Sturm,Felix von-Zweydorf,Felix von-Zweydorf,Lasse Pihlstrøm,Francesco Raimondi,Robert B. Russell,Peter Lichtner,Moinak Banerjee,Syam Krishnan,Roopa Rajan,Divya Kalikavil Puthenveedu,Sun Ju Chung,Peter Bauer,Olaf Riess,Christian Johannes Gloeckner,Rejko Krüger,Thomas Gasser,Thomas Gasser,Manu Sharma +20 more
TL;DR: Genetic variability in LRRK2 has been unequivocally established as a major risk factor for familial and sporadic forms of PD in ethnically diverse populations.
Journal ArticleDOI
Perspectives on Translational Genomics and Public Health in India.
TL;DR: The relevance, importance, and translational impediments of contemporary advances to implement public health principles into practice has neither been attempted nor impacted on disease burden or the authors' preparedness to prevent eventualities.
Journal ArticleDOI
The chronicles of modern movement disorders in India
TL;DR: A chronicle of Indian Movement Disorders is written based on personal interviews with various senior Movement Disorder specialists of India as mentioned in this paper, which is a right time to look back into the history of Indian Neurology with specific reference to the Movement Disorders and pen down these chronicles since the inception of modern neurology in India.
Journal ArticleDOI
Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson's disease.
TL;DR: The most frequent diagnosis was Parkinson's disease, followed by essential tremor and dystonia, and most patients were over 60 years of age, white, married and teachers.
References
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Japanese encephalitis (JE). Part I: clinical profile of 1,282 adult acute cases of four epidemics
N. B. S. Sarkari,Anup K. Thacker,S. P. Barthwal,V. K. Mishra,Shiv Prapann,Deepak Srivastava,M. Sarkari +6 more
TL;DR: The aim of this study is to detail the acute clinical profile (not viral) outcome and to classify the sequelae at discharge of 1,282 adult patients initially diagnosed as JE admitted during the epidemics of 1978, 1980, 1988, and 1989, on identical clinical presentation and CSF examination.
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Wilson's disease: An Indian perspective.
TL;DR: Assessment of impairment and severity and effect of various therapeutic interventions namely zinc sulphate on the long-term outcome and quality of life have also been studied.
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Parkin mutations in familial and sporadic Parkinson's disease among Indians
Shashi Chaudhary,Madhuri Behari,Maninder Dihana,Pazhayannur V. Swaminath,Shyla T. Govindappa,Sachi Jayaram,Vinay Goyal,Arindam Maitra,Uday B. Muthane,Ramesh C. Juyal,B.K. Thelma +10 more
TL;DR: A mutation frequency of 8.5% in Parkin gene among Indian PD patients is observed based on sequencing and gene dosage analysis of its exons and seven point mutations of which seven are novel and hitherto unreported are identified.
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Wilson disease mutation pattern with genotype-phenotype correlations from Western India: confirmation of p.C271* as a common Indian mutation and identification of 14 novel mutations.
Annu Aggarwal,Gursimran Chandhok,Theodor Todorov,Saloni Parekh,Sharada Tilve,Andree Zibert,Mohit Bhatt,Hartmut Schmidt +7 more
TL;DR: This study significantly adds to the emerging data from other parts of India suggesting that p.C271* may be the most frequent mutation across India, and may harbor a moderate to severely disabling phenotype with limited variability.
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A clinical profile of 103 patients with secondary movement disorders: correlation of etiology with phenomenology.
TL;DR: Studying patients with secondary movement disorders provides a unique opportunity to determine the correlation between the etiology and phenomenology of movement disorders.