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Movement disorders: Indian scenario: a clinico-genetic review.
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TLDR
Common problems of MDs in India with regard to epidemiology, clinical features and genetics are highlighted.Abstract:
Movement disorder (MD) is an important branch of neurology and has great potentiality in management because of improved diagnosis and therapeutic strategies. Over the last three decades, emphasis has been laid on the evaluation of various MDs in India by a limited number of interested neurologists and basic scientists. In this review, we want to highlight common problems of MDs in India with regard to epidemiology, clinical features and genetics.read more
Citations
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Admixing of MPTP-Resistant and Susceptible Mice Strains Augments Nigrostriatal Neuronal Correlates to Resist MPTP-Induced Neurodegeneration
TL;DR: The core neuroanatomical features of resilience against PD and evidence for ethnicity-based differential prevalence are presented and similar neural correlates of resilience are envisaged in the Anglo-Indian population.
Journal ArticleDOI
Understanding the role of genetic variability in LRRK2 in Indian population
Asha Kishore,Ashwin Ashok Kumar Sreelatha,Marc Sturm,Felix von-Zweydorf,Felix von-Zweydorf,Lasse Pihlstrøm,Francesco Raimondi,Robert B. Russell,Peter Lichtner,Moinak Banerjee,Syam Krishnan,Roopa Rajan,Divya Kalikavil Puthenveedu,Sun Ju Chung,Peter Bauer,Olaf Riess,Christian Johannes Gloeckner,Rejko Krüger,Thomas Gasser,Thomas Gasser,Manu Sharma +20 more
TL;DR: Genetic variability in LRRK2 has been unequivocally established as a major risk factor for familial and sporadic forms of PD in ethnically diverse populations.
Journal ArticleDOI
Perspectives on Translational Genomics and Public Health in India.
TL;DR: The relevance, importance, and translational impediments of contemporary advances to implement public health principles into practice has neither been attempted nor impacted on disease burden or the authors' preparedness to prevent eventualities.
Journal ArticleDOI
The chronicles of modern movement disorders in India
TL;DR: A chronicle of Indian Movement Disorders is written based on personal interviews with various senior Movement Disorder specialists of India as mentioned in this paper, which is a right time to look back into the history of Indian Neurology with specific reference to the Movement Disorders and pen down these chronicles since the inception of modern neurology in India.
Journal ArticleDOI
Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson's disease.
TL;DR: The most frequent diagnosis was Parkinson's disease, followed by essential tremor and dystonia, and most patients were over 60 years of age, white, married and teachers.
References
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Journal ArticleDOI
A novel COMMD1 mutation Thr174Met associated with elevated urinary copper and signs of enhanced apoptotic cell death in a Wilson Disease patient.
Arnab Gupta,Arnab Gupta,Ishita Chattopadhyay,S Mukherjee,Mainak Sengupta,Shyamal Kumar Das,Kunal Ray +6 more
TL;DR: In a patient showing apoptotic symptoms and high urinary copper surpassing normal WD levels, a novel, putative mutation in COMMD1 is identified and genotype-phenotype correlation between the detected changes and the atypical presentation of the WD patient is examined.
Journal ArticleDOI
Mutational screening of the parkin gene among South Indians with early onset Parkinson’s disease
TL;DR: The first report of parkin mutations from India and the first report from a non-white, non-oriental population of early onset Parkinson’s disease (PD) is reported.
Journal ArticleDOI
Molecular analysis of Huntington's disease and linked polymorphisms in the Indian population.
Quasar Saleem,Quasar Saleem,Sahadev Roy,U. Murgood,R. Saxena,I.C. Verma,Anuranjan Anand,Uday B. Muthane,S. Jain,Samir K. Brahmachari,Samir K. Brahmachari +10 more
TL;DR: To understand the population variation and haplotypes of Huntington's disease in India, CAG repeats at the HD locus together with closely linked polymorphisms in both HD patients and normal controls are analysed.
Journal Article
Quality of life in Parkinson's disease--Indian scenario.
TL;DR: The QoL deteriorates with H-Y staging, the UPDRS score, not with advancing age as seen in other studies, and the family and community relations were not significantly affected with advancing disease.
Journal ArticleDOI
Association of Polymorphism in Cytochrome P450 2D6 and N-Acetyltransferase-2 with Parkinson’s Disease
TL;DR: Investigation of association of polymorphism in cytochrome P450 2D6 (CYP2D6) and N-acteyltransferase-2 (NAT2), that are involved in the metabolism and detoxification of chemicals causing Parkinson disease (PD) like symptoms, with PD demonstrated the importance of gene-gene interactions in determining susceptibility to PD.