Journal ArticleDOI
Multisite phosphorylation provides sophisticated regulation of transcription factors.
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TLDR
Studies on transcription factors such as heat shock factor 1, p53 and nuclear factor of activated T cells (NFAT) illustrate recent progress in solving the dynamic nature of transcriptional regulation by multisite phosphorylation.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2002-12-01. It has received 326 citations till now. The article focuses on the topics: Phosphorylation cascade & NFATC Transcription Factors.read more
Citations
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The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression
TL;DR: The cellular signaling pathways identified as important regulators of inflammation are the signal transduction cascades mediated by the nuclear factor-kappaB and the activator protein-1, which can both be modulated by glucocorticoids.
Journal ArticleDOI
Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1
Takashi Furihata,Kyonoshin Maruyama,Yasunari Fujita,Taishi Umezawa,Riichiro Yoshida,Kazuo Shinozaki,Kazuko Yamaguchi-Shinozaki +6 more
TL;DR: The results indicate that the ABA-dependent multisite phosphorylation of AREB1 regulates its own activation in plants.
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Heat shock response modulators as therapeutic tools for diseases of protein conformation.
TL;DR: This review addresses the regulation of molecular chaperones and components of protein homeostasis by heat shock transcription factor 1 (HSF1), the master stress-inducible regulator, and the current understanding of pharmacologically active small molecule regulators of the heat shock response as a therapeutic strategy for protein conformational diseases.
Journal ArticleDOI
PDSM, a motif for phosphorylation-dependent SUMO modification.
Ville Hietakangas,Julius Anckar,Henri A. Blomster,Mitsuaki Fujimoto,Jorma J. Palvimo,Akira Nakai,Lea Sistonen +6 more
TL;DR: As the first recurrent sumoylation determinant beyond the consensus tetrapeptide, the PDSM provides a valuable tool in predicting new SUMO substrates.
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Genome-wide analysis of the biology of stress responses through heat shock transcription factor.
TL;DR: The whole-genome analyses used to identify virtually all of the direct transcriptional targets of yeast HSF provide novel insights into the role of HSF in growth, development, disease, and aging and in the complex metabolic reprogramming that occurs in all cells in response to stress.
References
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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
TL;DR: Recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation ofNFAT proteins with other transcription factors to regulate the expression of inducible genes are discussed.
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Signaling--2000 and beyond.
TL;DR: The important findings in the history of signal transduction are adequately covered in many reviews, and I have therefore cited reviews that discuss the seminal papers.
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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
TL;DR: The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?
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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
TL;DR: The protective role of HSPs is a measure of their capacity to assist in the repair of protein damage, through their chaperoning effects on proteins, protect cells from many forms of stress-induced cell damage and could influence the course of disease.