Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
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TLDR
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.Abstract:
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations
in bacteria, but that virus-resisting mutations are spontaneous. Their "fluctuation test" theory demonstrated that
bacteria were ideal subjects for genetic research.read more
Citations
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Book ChapterDOI
What is a quasispecies
TL;DR: The quasispecies concept has been shown to affect the pathway of evolution and has been studied on RNA viruses which have a particularly high mutation rate.
Journal ArticleDOI
The unexhausted potential of E. coli
TL;DR: Findings have shed light on aspects of its biology and ecology that pose far-reaching questions and illustrate how an appreciation of E. coli's natural history can expand its value as a model organism.
Book
Philosophy of experimental biology
TL;DR: In this paper, the nature of explanations and reductionism are discussed and a discussion of the role of explanations in scientific inference is presented in the context of ontogeny and scientific realism in search of the truth.
Journal ArticleDOI
Coevolutionary arms races between bacteria and bacteriophage.
TL;DR: A computational and theoretical framework for analyzing rapid coevolutionary dynamics of bacteriophage and bacteria in their ecological context and finds that multiple quasispecies of bacteria and phage can coexist in a homogeneous medium with a single resource.
Journal ArticleDOI
Recombination in Adaptive Mutation
TL;DR: Results indicate that the molecular mechanism by which adaptive mutation occurs includes recombination, and no such association is seen for spontaneous mutation in growing cells.
References
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Journal ArticleDOI
Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections
TL;DR: A bacteria-resistant-virus-resistant line is being developed from a cross between bacteria-susceptible-v virus-resistant and bacteria- resistant- virus-sUSceptible lines, which proved uniformly susceptible to a strain of mouse passage rabies virus.
Journal ArticleDOI
A Description of Some Color Variants Produced by Serratia marcescens, Strain 274
TL;DR: The work reported in this paper is of a preliminary nature and is concerned with the selection of a strain suitable for intensive study, the development of a special medium, and the recognition and characterization of specific variant types.